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1 | INTERNATIONAL WORKSHOP on “Insecticide resistance in vectors of emerging arboviruses: Challenge and prospects for vector control” 05 – 08 December 2016, Windsor Marapendi, Rio de Janeiro, BRAZIL Schedule and program of the International workshop December 05th 2016 - Windsor Marapendi - 08:15-08:50 Registration & welcoming of participants 08:50-09:30 Workshop opening: Welcoming addresses Room: Jurunas I + Nauas I 08:50-08:55 Welcome address from the Brazilian Ministry of Health Dr. Ana Carolina Santelli, Coordinator of vector borne diseases Program, Brazil 08:55-09:00 Welcome address from the Oswaldo Cruz Institute Dr. Eliane Veiga da Costa, Vice- director, Oswaldo Cruz Institute, Brazil 09:00-09:05 Welcome address from the French Ministry of Foreign Affairs in Brazil Mr. Brice Roquefeuil, Consul general of France, Brazil 09:05-09:10 Welcome address from the World Health Organization Neglected Tropical Diseases Department Dr. Raman Velayudhan, Coordinator of vector ecology and management, Switzerland 09:10-09:15 Welcome address from the World Health Organization Tropical Diseases Research programme Dr. Florence Fouque, Team Leader on vectors, Switzerland 09:15-09:20 Welcome address from the Pan American Health Organization Dr. Haroldo Bezerra, Advisor Public Health Entomology, USA 09:20-09:30 Objectives of the workshop and presentation of the Worldwide Insecticide resistance Network Dr. Ademir Martins, Oswaldo Cruz Institute, Brazil Dr. Vincent Corbel, Institut de Recherche pour le Développement, France

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1 |

INTERNATIONAL WORKSHOP on “Insecticide resistance in vectors of

emerging arboviruses: Challenge and prospects for vector control”

05 – 08 December 2016, Windsor Marapendi, Rio de Janeiro, BRAZIL

Schedule and program of the International workshop

December 05th 2016 - Windsor Marapendi -

08:15-08:50 Registration & welcoming of participants

08:50-09:30 Workshop opening: Welcoming addresses

Room: Jurunas I + Nauas I

08:50-08:55 Welcome address from the Brazilian Ministry of Health Dr. Ana Carolina Santelli, Coordinator of vector borne diseases Program, Brazil

08:55-09:00 Welcome address from the Oswaldo Cruz Institute Dr. Eliane Veiga da Costa, Vice-director, Oswaldo Cruz Institute, Brazil

09:00-09:05 Welcome address from the French Ministry of Foreign Affairs in Brazil Mr. Brice Roquefeuil, Consul general of France, Brazil

09:05-09:10 Welcome address from the World Health Organization Neglected Tropical Diseases Department

Dr. Raman Velayudhan, Coordinator of vector ecology and management, Switzerland

09:10-09:15 Welcome address from the World Health Organization Tropical Diseases Research programme

Dr. Florence Fouque, Team Leader on vectors, Switzerland

09:15-09:20 Welcome address from the Pan American Health Organization Dr. Haroldo Bezerra, Advisor Public Health Entomology, USA

09:20-09:30 Objectives of the workshop and presentation of the Worldwide Insecticide resistance Network

Dr. Ademir Martins, Oswaldo Cruz Institute, Brazil Dr. Vincent Corbel, Institut de Recherche pour le Développement, France

2 |

INTERNATIONAL WORKSHOP on “Insecticide resistance in vectors of

emerging arboviruses: Challenge and prospects for vector control”

05 – 08 December 2016, Windsor Marapendi, Rio de Janeiro, BRAZIL

December 05th 2016 (continued)

09:30-12:30 Scientific Session 1: Causes and consequences of the expansion of arboviral diseases and vectors

Room: Jurunas I + Nauas I

Chair persons: Dr. Audrey Lenhart (US CDC)/ Dr. Florence Fouque (WHO-TDR)

09:30-09:50 Epidemic arboviral diseases: an increasing problem in the 21st century Pr. Annelies Wilder-Smith, Lee Kong Chian School of Medicine, Singapore

09:50-10:10 Zika outbreak in Brazil: Causes and consequences Dr. Pedro Vasconcelos, Instituto Evandro Chagas, Brazil

10:10-10:30 WHO vector control response and preparedness for emerging arboviruses

Dr. Raman Velayudhan, World Health Organization, Switzerland

10:30-10:45 Discussions

10:45-11:15 Coffee break & Poster session (Foyer)

Chair persons: Pr. Dina Fonseca (Rutgers U.) / Dr. Raman Velayudhan (WHO)

11:15-11:35 Insecticide resistance and the globalization of Aedes mosquitoes Pr. Dina Fonseca, Rutgers University, USA

11:35-11:55 Integrated Vector Management for arbovirus control Dr. Anne Wilson, Durham University, UK

11:55-12:15 Evolution of insecticide resistance in vectors of human diseases Dr. Mylène Weill, Institut des Sciences de l'Evolution de Montpellier, France

12 :15-12:30 Discussions

12:30-14:00 Lunch (at hotel Restaurant)

3 |

INTERNATIONAL WORKSHOP on “Insecticide resistance in vectors of

emerging arboviruses: Challenge and prospects for vector control”

05 – 08 December 2016, Windsor Marapendi, Rio de Janeiro, BRAZIL

December 05th 2016 (continued)

14:00-17:45 Scientific Session 2: Insecticide resistance in arbovirus vectors

Room: Jurunas I + Nauas I

Chair persons: Dr. Catherine Moyes (Oxford U.) / Dr. Mamadou Coulibaly (USTTB)

14:00-14:10 Status of insecticide resistance in arboviruses vectors in Europe Dr. Beniamino Caputo, Sapienza University of Rome, Italy

14:10-14:20 Current status of insecticide resistance in Aedes aegypti and Aedes albopictus in the African region

Dr. Mamadou Coulibaly, University of Sciences, Techniques and Technologies of Bamako, Mali

14:20-14:30 Status of resistant of Aedes aegypti and Aedes albopictus to different insecticides in Eastern Mediterranean Region

Dr. Hassan Vatandoost, Tehran University of Medical Science, Iran

14:30-14:40 Status of insecticide resistance in arboviruses vectors in China Dr. Feng-Xia Meng, Chinese Center for Disease Control and Prevention, China

14:40-14:50 Status of insecticide resistance in arboviruses vectors in India Dr. Kamaraju Raghavendra, National Institute for Malaria Research, India

14:50-15:00 Strengthening integrated vector management in the Americas: The challenge of insecticide resistance and next steps

Dr. Haroldo Bezerra, Pan American Health Organization, USA

15:00-15:10 Status of insecticide resistance in arboviruses vectors in South America Dr. Constancia Ayres, Fundação Oswaldo Cruz, Brazil

15:10-15:20 Aedes aegypti Management Strategies for Dengue Control in Cuba Dr. Juan Bisset, Instituto de Medicina Tropical Pedro Kouri, Cuba

15:20-15:30 Discussions

15:30-16:00 Coffee break & Poster session (Foyer)

4 |

INTERNATIONAL WORKSHOP on “Insecticide resistance in vectors of

emerging arboviruses: Challenge and prospects for vector control”

05 – 08 December 2016, Windsor Marapendi, Rio de Janeiro, BRAZIL

December 05th 2016 (continued)

Chair persons: Dr. David Weetman (LSTM) / Dr. Jean-Philippe David (CNRS)

16:00-16:15 Geographical distribution of insecticide resistance in key arbovirus vectors Dr. Catherine Moyes, Oxford University, UK

16:15-16:30 Operational Impact of insecticide resistance in arbovirus vectors Dr. Azael Che Mendoza, Universidad Autónoma de Yucatán, Mexico

16:30-16:45 Genetics of insecticide resistance - target-site modifications Dr. Shinji Kasai, National Institute of Infectious Diseases, Japan

16:45-17:00 The genetics of metabolic resistance to insecticides in arbovirus vectors - From theory to improved resistance management strategies

Dr. Jean-Philippe David, Centre National de la Recherche Scientifique, France

17:00-17:15 The role of individual genes and mutations in insecticide resistance and the value of molecular diagnostics and bioassays for detecting the trait

Dr. John Vontas, Foundation for Research and Technology Hellas, Greece

17:15-17:30 Insecticide Resistance Management strategies applicable to mosquito vectors of arboviruses

Dr. Isabelle Dusfour, Institut Pasteur de la Guyane, France

17:30-17:45 Discussions

December 06th 2016 - Windsor Marapendi -

09:00-12:30 Scientific Session 3: Innovative vector control approaches for the vectors of emerging arboviruses

Room: Jurunas I + Nauas I

Chair persons: Dr. Nicole Achee (NDU) / Dr. Joao Pinto (IHTM)

09:00-09:15 New paradigms for the control of arbovirus vectors: an overview Dr. Nicole Achee, Notre Dame University, USA

09:15-09:30 Potential use of insecticide mixtures/combinations for the control of arboviruses vectors in Martinique (FWI)

Dr. André Yébakima, Collectivité territoriale de la Martinique, France

5 |

INTERNATIONAL WORKSHOP on “Insecticide resistance in vectors of

emerging arboviruses: Challenge and prospects for vector control”

05 – 08 December 2016, Windsor Marapendi, Rio de Janeiro, BRAZIL

December 06th 2016 (continued)

09:30-09 :45 New repellents for personal protection against arbovirus vectors Dr. Rui-De Xue, Anastasia Mosquito Control District, USA

09:45-10:00 Treated materials as personal protection against the vectors of dengue and Zika

Dr. James Orsborne, London School of Hygiene & Tropical Medicine, UK

10:00-10:15 Spatial repellents for controlling arboviruses Dr. John Grieco, Notre Dame University, USA

10:15-10:30 Discussion

10:30-11:00 Coffee break & Poster session (Foyer)

Chair persons: Dr. Lee Ching Ng (NEA) / Dr. Isabelle Dusfour (Pasteur Institut)

11:00-11:15 Biological and chemical synergistic agents to overcome resistance in mosquitoes

Dr. Bruno Lapied, University of Angers, France

11:15-11:30 Attractive toxic sugar baits for controlling arboviruses Dr. Whitney Qualls, Texas Department of State Health Services, USA

11:30-11:45 A summary of autocidal methods against Aedes aegypti and Aedes albopictus in the USA

Dr. Stephan Dobson, University of Kentucky, USA

11:45-12:00 Improvement of transgenic strains of Aedes Aegypti for the control of arbovirus transmission in Brazil

Dr. Margareth Capurro, University of São Paulo, Brazil

12:00-12:15 Wolbachia-based population reduction strategy in Singapore Dr. Lee Ching Ng, National Environment Agency, Singapore

12:15-12:30 Discussion

12:30-14:00 Lunch (at hotel Restaurant)

6 |

INTERNATIONAL WORKSHOP on “Insecticide resistance in vectors of

emerging arboviruses: Challenge and prospects for vector control”

05 – 08 December 2016, Windsor Marapendi, Rio de Janeiro, BRAZIL

December 06th 2016 (continued)

14:00-17:30 Industry Session: Private-public partnership for the development of new tools for arbovirus vector control

Room: Jurunas I + Nauas I

Chair persons: Dr. Fabrice Chandre (IRD) / Pr. Hassan Vatandoost (TUMS)

14:00-14:15 The challenge of insecticide resistance – an industry perspective Mr. John Lucas, Insecticide Resistance Action Committee, UK

14:15-14:30 New tools for tracking insecticide resistance in Aedes mosquitoes (IR mapper)

Mrs. Melinda Hadi, Vestergaard Frandsen, Switzerland

14:30-14:45 IVCC portfolio of new insecticide products applicable to arbovirus vector control

Dr. Julian Entwistle, Innovative Vector Control Consortium, UK

14:45-15:00 A promising new combination for space spray to control mosquitoes in areas of established or emerging resistance to conventional insecticides

Mr. Frédéric Schmitt, Bayer, France

15:00-15:15 Insecticide Paper - A New Tool for Use Within an Integrated Approach Mr. Kevin Riozzi, Yanco, UK

15:15-15:30 Discussion

15:30-16:00 Coffee break & Poster session (Foyer)

Chair persons: Dr. John Vontas (FORTH) / Dr. Kamaraju Raghavendra (NIMR)

16:00-16:15 Why the combination of two passive and one active mosquito trap may well be a control tool worthy of attention

Dr. Andreas Rose, Biogents AG, Germany

16:15-16:30 Larval control of Aedes aegypti using SumiLarv®2MR, a new long lasting matrix-release formulation containing pyriproxyfen

Mr. Yoshinori Shono, Sumitomo, Japan

16:30-16:45 Resistance management in IVM programs based on operational use of Bacillus thruingiensis israelensis strain AM65-52 for the control of dengue, chikungunya, and Zika vectors

Mr. Peter DeChant, ValentBioSciences, USA

16:45-17:00 Investigation of Spinosad as a candidate for temephos resistance management in Brazil

Dr. William Jany, Clarke International LLC, USA

7 |

INTERNATIONAL WORKSHOP on “Insecticide resistance in vectors of

emerging arboviruses: Challenge and prospects for vector control”

05 – 08 December 2016, Windsor Marapendi, Rio de Janeiro, BRAZIL

December 06th 2016 (continued)

17:00-17:15 Acoustic Larvicide™ and the Larvasonic™ Product Line Provides a Resistant Tolerant, Environmentally Friendly, Integrated Approach for Urban Mosquito Control

Mr. Herbert Nyberg, New mountain Innovations, USA

17:15-17:30 Discussion

18:30 – 21:30 Cocktail & dinner (Rooftop)

December 07th 2016 - Windsor Marapendi -

09:00-12:30 Round tables

09:00-10:45 Round table 1: New tools for arboviruses vector control All members

Room: Potiguara I

Chairman: Dr. Vincent Corbel (IRD)

Rapporteur: Dr. Nicole Achee (NDU)

09:00-10:45 Round table 2: Improve insecticide resistance surveillance and management

All members

Room: Jurunas II

Chairman: Dr. Jean-Philippe David (CNRS)

Rapporteur: Dr. David Weetman (LSTM)

10:45-11:45 Coffee break (Foyer)

11:45-12:15 Conclusions / Recommendations Rapporteurs of each round table

12:15-12:30 Official closure of the workshop from the World Health Organization Tropical Diseases Research programme

Dr. Florence Fouque, TDR-World Health Organization, Switzerland

12:30-14:00 Lunch (at hotel Restaurant)

8 |

INTERNATIONAL WORKSHOP on “Insecticide resistance in vectors of

emerging arboviruses: Challenge and prospects for vector control”

05 – 08 December 2016, Windsor Marapendi, Rio de Janeiro, BRAZIL

December 07th 2016 (continued)

14:00-18:00 Internal meeting: 2nd WIN meeting

Room: Potiguara I

14:00-14:30 Meeting with the External Advisory board WIN members + External Advisory

Board

14:30-17:00 Network orientation and management WIN members

17:00-18:00 WIN Executive committee meeting WIN members

December 08th 2016 - Oswaldo Cruz Institute -

09:00-12:00 Internal meeting Room: Emmanuel Dias Auditorium (building Arthur Neiva)

Round table: Mutual benefit of crossed entomological and geographical approach of vector borne diseases

On invitation

Workshop organization committee

Dr. Vincent CORBEL PI of the WIN

[email protected]

Claire DUROT Project Manager of the WIN

[email protected]

Dr. Jean-Philippe DAVID Co-Pi of the WIN

[email protected]

Dr. Ademir J MARTINS Jr [email protected]

9 |

INTERNATIONAL WORKSHOP on “Insecticide resistance in vectors of

emerging arboviruses: Challenge and prospects for vector control”

05 – 08 December 2016, Windsor Marapendi, Rio de Janeiro, BRAZIL

Workshop Sponsors

10 |

INTERNATIONAL WORKSHOP on “Insecticide resistance and emerging arboviruses: Challenge and prospects”

05 – 08 December 2016, Windsor Marapendi, Rio de Janeiro, BRAZIL

List of Speakers

First name Name Institution Country First name Name Institution Country

1 Dr Nicole Achee University of Notre Dame USA 16 Dr Florence Fouque World Health Organization-TDR

Switzerland

2 Dr Constancia Ayres Fundação Oswaldo Cruz Brazil 17 Dr John Grieco University of Notre Dame USA

3 Dr Haroldo Bezerra Pan American Health Organization/WHO

USA 18 Mrs Melinda Hadi Vestergaard Frandsen Switzerland

4 Dr Juan Bisset Instituto de Medicina Tropical Pedro Kouri

Cuba 19 Dr William Jany Clarke International LLC USA

5 Dr Margareth Capurro University of São Paulo Brazil 20 Dr Shinji Kasai National Institute of Infectious Diseases

Japan

6 Dr Beniamino Caputo Sapienza University of Rome

Italy 21 Mr John Lucas Insecticide Resistance Action Committee

UK

7 Dr Azael Che Mendoza

Universidad Autónoma de Yucatán

Mexico 22 Dr Ademir J Martins Jr. Fundação Oswaldo Cruz Brazil

8 Dr Vincent Corbel Institut de Recherche pour le Développement

France 23 Dr Feng-Xia Meng Chinese Center for Disease Control and Prevention

China

9 Dr Mamadou Coulibaly University of Sciences, Techniques and Technologies of Bamako

Mali 24 Dr Catherine Moyes Oxford University UK

10 Dr Jean-Philippe

David Centre National de la Recherche Scientifique

France 25 Dr Lee Ching Ng National Environment Agency

Singapore

11 Mr Peter DeChant Valent BioSciences Corporation

USA 26 Dr James Orsborne Liverpool School of Hygiene &Tropical Medicine

UK

12 Dr Stephan L Dobson University of Kentucky USA 27 Dr Whitney Qualls Texas Department of State Health Services

USA

13 Dr Isabelle Dusfour Institut Pasteur de la Guyane

French Guyana

28 Dr Kamaraju Raghavendra National Institute for Malaria Research

India

14 Dr Julian Entwistle Innovative Vector Control Consortium

UK 29 Dr Andreas Rose Biogents AG Germany

15 Dr Dina Fonseca Rutgers University USA 30 Mr Kévin Riozzi Yanco UK

11 |

INTERNATIONAL WORKSHOP on “Insecticide resistance and emerging arboviruses: Challenge and prospects”

05 – 08 December 2016, Windsor Marapendi, Rio de Janeiro, BRAZIL

List of Speakers (continued)

First name Name Institution Country First name Name Institution Country

31 Mr Frédéric Schmitt Bayer France 36 Dr Anne Wilson Durham University UK

32 Dr Pedro Vasconcelos Instituto Evandro Chagas Brazil 37 Dr André Yébakima Collectivité territoriale de la Martinique

France

33 Dr Hassan Vatandoost Tehran University of Medical Science

Iran 38 Dr Rui-de Xue Anastasia Mosquito Control District

USA

34 Dr Raman Velayudhan World Health Organization-NTD

Switzerland 39 Dr Mylène Weill Institut des Sciences et de l’Evolution de Montpellier

France

35 Dr John Vontas Foundation for Research and Technology Hellas

Greece 40 Dr Annelies Wilder-Smith Lee Kong Chian School of Medicine

Singapore

Workshop sponsors

12 |

INTERNATIONAL WORKSHOP on “Insecticide resistance and emerging arboviruses: Challenge and prospects”

05 – 08 December 2016, Windsor Marapendi, Rio de Janeiro, BRAZIL

List of represented institutions

Universities & Research institutions

Country Universities & Research

institutions Country

Universities & Research institutions

Country

1 Bayero University Nigeria 16 Institut de Recherche pour le Développement

France 31 Universidade Castelo Branco Brazil

2 Centre National de la Recherche Scientifique

France 17 Instituto Nacional do Cancer Brazil 32 Universidade Iguacu Brazil

3 Durham University UK 18 Institut des Sciences et de l’Evolution de Montpellier

France 33 University of Kentucky USA

4 Federal University of Rio de Janeiro Brazil 19 Liverpool School of Hygiene & Tropical Medicine

UK 34 University of Minas Gerais Brazil

5 Fundação Oswaldo Cruz Brazil 20 Lee Kong Chian School of Medicine Singapore 35 University of São Paulo Brazil

6 Foundation for Research and Technology Hellas

Greece 21 National Environment Agency Singapore 36 University of Sciences, Techniques and Technologies of Bamako

Mali

7 Instituto Brasileiro de Medicina em Reabilitação

Brazil 22 National Institute for Malaria Research

India 37 Yale University USA

8 Instituto Evandro Chagas Brazil 23 National Institute of Amazonian Research

Brazil

9 Instituto de Higiene and Medicina Tropical

Portugal 24 Notre Dame University USA International organizations Country

10 Instituto de Investigaciones Científicas y Técnicas para la Defensa

Argentina 25 Oxford University UK 1 Pan American Health Organization/WHO

Brazil/USA

11 Instituto de Medicina Tropical Pedro Kouri

Cuba 26 Rutgers University USA 2 World Health Organization-TDR Switzerland

12 Instituto de Medicina Tropical de São Paulo

Brazil 27 Sapienza University of Rome Italy 3 World Health Organization-NTD Switzerland

13 Institut Pasteur de la Guyane French Guyana

28 Tehran University of Medical Science Iran

14 Institut Pasteur de Madagascar Madagascar 29 Universidad Autónoma de Yucatán Mexico

15 Instituto de Pesquisas Científicas e Tecnológicas do Estado do Amapá

Brazil 30 University of Angers France

13 |

INTERNATIONAL WORKSHOP on “Insecticide resistance and emerging arboviruses: Challenge and prospects”

05 – 08 December 2016, Windsor Marapendi, Rio de Janeiro, BRAZIL

List of represented institutions (continued)

National & Governmental supported agencies

Country National & Governmental supported agencies

Country Private company Country

1 Anastasia Mosquito Control District USA 16 Secretaria da Saúde – Governo do Estadao de São Paulo

Brazil 10 Insecticide Resistance Action Committee (IRAC)

UK

2 Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement et du travail

France 17 Texas Department of State Health Services

USA 11 Innovative Vector Control Consortium (IVCC)

UK

3

Brazilian Federation of Synanthropic Pest and Vector Control Associations

Brazil 18 US Agency for International Development

USA 12 Malva Ltda Brazil

4 Collectivité territoriale de la Martinique

France 19 US Centers for Disease Control and Prevention

USA 13 Matabi Do Brasil Brazil

5 Chinese Center for Disease Control and Prevention China

China 14 New Mountain Innovations USA

6 Federal Ministry of Health Sudan Private company Country 15 One Label Agencies Kenya

7 French Ministry of Foreign Affairs Brazil 1 Bayer Brazil/France 16 OGN Astral Brazil

8 Ministry of Health Angola 2 BASF S.A Brazil 17 RENTOKIL Brazil

9 Ministry of Health Belize 3 Biogents AG Germany 18 Sanofi Pasteur Brazil

10 Ministry of Health Brazil 4 Clarke International LLC USA 19 SAPO Saneamento Ambiental ltda Brazil

11 Ministry of Health Liberia 5 Concordia Public Affairs Strategies Brazil 20 Sumitomo Chemical Brazil/Japan/UK

12 Ministry of Health Malaysia 6 FMC Corporation USA 21 Syngenta Brazil

13 National Environment Agency Singapore 7 Goizper Spain 22 Valent BioSciences USA

14 National Institute of Infectious diseases

Japan 8 Guarany Brazil 23 Vestergaard Frandsen Switzerland

15 Secretaria Municipal de Saude do Rio de Janeiro

Brazil 9 HCS7 Consultoria Brazil 24 Yanco UK