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TRANSPLANTE RENAL: IMPLANTE DO ENXERTO E COMPLICAÇÕES

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Page 1: Aula Transplante Renal

TRANSPLANTE RENAL IMPLANTE DO ENXERTO E

COMPLICACcedilOtildeES

Incisatildeo do receptor

Incisatildeo de

Gibson e Hockey-

stick

Acesso retroperitoneal

IMPLANTE VASCULAR

Anastomose tradicional anastomose arterial primeiro reduz tempo de oclusatildeo venosa e risco de TVP Veia costuma ser mais longa e por isso maior risco de kink e trombose da veia Dar preferecircncia do rim doado esquerdo (veia mais longa) a ser implantado na fossa iliacuteaca direita

IMPLANTE VASCULAR FIO PROLENE 6-0 NA VEIA E 5-0 NA ARTERIA

SUSPRESAS

IMPLANTE VASCULAR

Segunda opccedilatildeo complicaccedilatildeo impotecircncia

IMPLANTE VASCULAR

IMPLANTE VASCULAR

Outra opccedilatildeo

MAIS SURPRESAS ARTEacuteRIAS MUacuteLTIPLAS

TEacuteCNICAS DE RECONSTRUCcedilAtildeO ARTERIAL DO ENXERTO

TEacuteCNICAS PARA ALONGAR VEIA RENAL

DOADOR RENAL INFANTIL

DIURESE PRESENTE

IMPLANTE URETERAL

Lich-Gregoir (MacKinnon)

IMPLANTE URETERAL

IMPLANTE URETERAL

bull OUTRAS TEacuteCNICAS DE URETERONEOCISTOSTOMIA

ndash Politano-Leadbetter

ndash Taniguch

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

bull DIRETAS

bull Cushing

bull D mellitus bull GastriteUGD

bull Pancreatite

bull Mielodepressatildeo

bull Nefrotoxicidade

bull Hepatotoxicidade

bull Alteraccedilatildeo comportamental

bull Catarata

bull Necrose oacutessea

bullINDIRETAS

bull Infecccedilotildees

- Fungos

- Bacteacuterias

- Viacuterus

- Parasitas

bull Neoplasias

Kidney transplant recipients are more likely to develop cancer than age-matched subjects in the general population and patients wait-listed for deceased donor renal transplantation ( Kasiske et al 2004)

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

Complicaccedilatildeo imunoloacutegica

Complicaccedilotildees vasculares

bull Estenose de arteacuteria renal 17

bull Trombose de arteacuteria renal 17

bull Trombose de veia renal 14

bull Linfocele 12

Risaliti A et all G Ital Nefrol 2004

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 2: Aula Transplante Renal

Incisatildeo do receptor

Incisatildeo de

Gibson e Hockey-

stick

Acesso retroperitoneal

IMPLANTE VASCULAR

Anastomose tradicional anastomose arterial primeiro reduz tempo de oclusatildeo venosa e risco de TVP Veia costuma ser mais longa e por isso maior risco de kink e trombose da veia Dar preferecircncia do rim doado esquerdo (veia mais longa) a ser implantado na fossa iliacuteaca direita

IMPLANTE VASCULAR FIO PROLENE 6-0 NA VEIA E 5-0 NA ARTERIA

SUSPRESAS

IMPLANTE VASCULAR

Segunda opccedilatildeo complicaccedilatildeo impotecircncia

IMPLANTE VASCULAR

IMPLANTE VASCULAR

Outra opccedilatildeo

MAIS SURPRESAS ARTEacuteRIAS MUacuteLTIPLAS

TEacuteCNICAS DE RECONSTRUCcedilAtildeO ARTERIAL DO ENXERTO

TEacuteCNICAS PARA ALONGAR VEIA RENAL

DOADOR RENAL INFANTIL

DIURESE PRESENTE

IMPLANTE URETERAL

Lich-Gregoir (MacKinnon)

IMPLANTE URETERAL

IMPLANTE URETERAL

bull OUTRAS TEacuteCNICAS DE URETERONEOCISTOSTOMIA

ndash Politano-Leadbetter

ndash Taniguch

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

bull DIRETAS

bull Cushing

bull D mellitus bull GastriteUGD

bull Pancreatite

bull Mielodepressatildeo

bull Nefrotoxicidade

bull Hepatotoxicidade

bull Alteraccedilatildeo comportamental

bull Catarata

bull Necrose oacutessea

bullINDIRETAS

bull Infecccedilotildees

- Fungos

- Bacteacuterias

- Viacuterus

- Parasitas

bull Neoplasias

Kidney transplant recipients are more likely to develop cancer than age-matched subjects in the general population and patients wait-listed for deceased donor renal transplantation ( Kasiske et al 2004)

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

Complicaccedilatildeo imunoloacutegica

Complicaccedilotildees vasculares

bull Estenose de arteacuteria renal 17

bull Trombose de arteacuteria renal 17

bull Trombose de veia renal 14

bull Linfocele 12

Risaliti A et all G Ital Nefrol 2004

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 3: Aula Transplante Renal

IMPLANTE VASCULAR

Anastomose tradicional anastomose arterial primeiro reduz tempo de oclusatildeo venosa e risco de TVP Veia costuma ser mais longa e por isso maior risco de kink e trombose da veia Dar preferecircncia do rim doado esquerdo (veia mais longa) a ser implantado na fossa iliacuteaca direita

IMPLANTE VASCULAR FIO PROLENE 6-0 NA VEIA E 5-0 NA ARTERIA

SUSPRESAS

IMPLANTE VASCULAR

Segunda opccedilatildeo complicaccedilatildeo impotecircncia

IMPLANTE VASCULAR

IMPLANTE VASCULAR

Outra opccedilatildeo

MAIS SURPRESAS ARTEacuteRIAS MUacuteLTIPLAS

TEacuteCNICAS DE RECONSTRUCcedilAtildeO ARTERIAL DO ENXERTO

TEacuteCNICAS PARA ALONGAR VEIA RENAL

DOADOR RENAL INFANTIL

DIURESE PRESENTE

IMPLANTE URETERAL

Lich-Gregoir (MacKinnon)

IMPLANTE URETERAL

IMPLANTE URETERAL

bull OUTRAS TEacuteCNICAS DE URETERONEOCISTOSTOMIA

ndash Politano-Leadbetter

ndash Taniguch

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

bull DIRETAS

bull Cushing

bull D mellitus bull GastriteUGD

bull Pancreatite

bull Mielodepressatildeo

bull Nefrotoxicidade

bull Hepatotoxicidade

bull Alteraccedilatildeo comportamental

bull Catarata

bull Necrose oacutessea

bullINDIRETAS

bull Infecccedilotildees

- Fungos

- Bacteacuterias

- Viacuterus

- Parasitas

bull Neoplasias

Kidney transplant recipients are more likely to develop cancer than age-matched subjects in the general population and patients wait-listed for deceased donor renal transplantation ( Kasiske et al 2004)

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

Complicaccedilatildeo imunoloacutegica

Complicaccedilotildees vasculares

bull Estenose de arteacuteria renal 17

bull Trombose de arteacuteria renal 17

bull Trombose de veia renal 14

bull Linfocele 12

Risaliti A et all G Ital Nefrol 2004

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 4: Aula Transplante Renal

IMPLANTE VASCULAR FIO PROLENE 6-0 NA VEIA E 5-0 NA ARTERIA

SUSPRESAS

IMPLANTE VASCULAR

Segunda opccedilatildeo complicaccedilatildeo impotecircncia

IMPLANTE VASCULAR

IMPLANTE VASCULAR

Outra opccedilatildeo

MAIS SURPRESAS ARTEacuteRIAS MUacuteLTIPLAS

TEacuteCNICAS DE RECONSTRUCcedilAtildeO ARTERIAL DO ENXERTO

TEacuteCNICAS PARA ALONGAR VEIA RENAL

DOADOR RENAL INFANTIL

DIURESE PRESENTE

IMPLANTE URETERAL

Lich-Gregoir (MacKinnon)

IMPLANTE URETERAL

IMPLANTE URETERAL

bull OUTRAS TEacuteCNICAS DE URETERONEOCISTOSTOMIA

ndash Politano-Leadbetter

ndash Taniguch

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

bull DIRETAS

bull Cushing

bull D mellitus bull GastriteUGD

bull Pancreatite

bull Mielodepressatildeo

bull Nefrotoxicidade

bull Hepatotoxicidade

bull Alteraccedilatildeo comportamental

bull Catarata

bull Necrose oacutessea

bullINDIRETAS

bull Infecccedilotildees

- Fungos

- Bacteacuterias

- Viacuterus

- Parasitas

bull Neoplasias

Kidney transplant recipients are more likely to develop cancer than age-matched subjects in the general population and patients wait-listed for deceased donor renal transplantation ( Kasiske et al 2004)

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

Complicaccedilatildeo imunoloacutegica

Complicaccedilotildees vasculares

bull Estenose de arteacuteria renal 17

bull Trombose de arteacuteria renal 17

bull Trombose de veia renal 14

bull Linfocele 12

Risaliti A et all G Ital Nefrol 2004

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 5: Aula Transplante Renal

SUSPRESAS

IMPLANTE VASCULAR

Segunda opccedilatildeo complicaccedilatildeo impotecircncia

IMPLANTE VASCULAR

IMPLANTE VASCULAR

Outra opccedilatildeo

MAIS SURPRESAS ARTEacuteRIAS MUacuteLTIPLAS

TEacuteCNICAS DE RECONSTRUCcedilAtildeO ARTERIAL DO ENXERTO

TEacuteCNICAS PARA ALONGAR VEIA RENAL

DOADOR RENAL INFANTIL

DIURESE PRESENTE

IMPLANTE URETERAL

Lich-Gregoir (MacKinnon)

IMPLANTE URETERAL

IMPLANTE URETERAL

bull OUTRAS TEacuteCNICAS DE URETERONEOCISTOSTOMIA

ndash Politano-Leadbetter

ndash Taniguch

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

bull DIRETAS

bull Cushing

bull D mellitus bull GastriteUGD

bull Pancreatite

bull Mielodepressatildeo

bull Nefrotoxicidade

bull Hepatotoxicidade

bull Alteraccedilatildeo comportamental

bull Catarata

bull Necrose oacutessea

bullINDIRETAS

bull Infecccedilotildees

- Fungos

- Bacteacuterias

- Viacuterus

- Parasitas

bull Neoplasias

Kidney transplant recipients are more likely to develop cancer than age-matched subjects in the general population and patients wait-listed for deceased donor renal transplantation ( Kasiske et al 2004)

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

Complicaccedilatildeo imunoloacutegica

Complicaccedilotildees vasculares

bull Estenose de arteacuteria renal 17

bull Trombose de arteacuteria renal 17

bull Trombose de veia renal 14

bull Linfocele 12

Risaliti A et all G Ital Nefrol 2004

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 6: Aula Transplante Renal

IMPLANTE VASCULAR

Segunda opccedilatildeo complicaccedilatildeo impotecircncia

IMPLANTE VASCULAR

IMPLANTE VASCULAR

Outra opccedilatildeo

MAIS SURPRESAS ARTEacuteRIAS MUacuteLTIPLAS

TEacuteCNICAS DE RECONSTRUCcedilAtildeO ARTERIAL DO ENXERTO

TEacuteCNICAS PARA ALONGAR VEIA RENAL

DOADOR RENAL INFANTIL

DIURESE PRESENTE

IMPLANTE URETERAL

Lich-Gregoir (MacKinnon)

IMPLANTE URETERAL

IMPLANTE URETERAL

bull OUTRAS TEacuteCNICAS DE URETERONEOCISTOSTOMIA

ndash Politano-Leadbetter

ndash Taniguch

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

bull DIRETAS

bull Cushing

bull D mellitus bull GastriteUGD

bull Pancreatite

bull Mielodepressatildeo

bull Nefrotoxicidade

bull Hepatotoxicidade

bull Alteraccedilatildeo comportamental

bull Catarata

bull Necrose oacutessea

bullINDIRETAS

bull Infecccedilotildees

- Fungos

- Bacteacuterias

- Viacuterus

- Parasitas

bull Neoplasias

Kidney transplant recipients are more likely to develop cancer than age-matched subjects in the general population and patients wait-listed for deceased donor renal transplantation ( Kasiske et al 2004)

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

Complicaccedilatildeo imunoloacutegica

Complicaccedilotildees vasculares

bull Estenose de arteacuteria renal 17

bull Trombose de arteacuteria renal 17

bull Trombose de veia renal 14

bull Linfocele 12

Risaliti A et all G Ital Nefrol 2004

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 7: Aula Transplante Renal

IMPLANTE VASCULAR

IMPLANTE VASCULAR

Outra opccedilatildeo

MAIS SURPRESAS ARTEacuteRIAS MUacuteLTIPLAS

TEacuteCNICAS DE RECONSTRUCcedilAtildeO ARTERIAL DO ENXERTO

TEacuteCNICAS PARA ALONGAR VEIA RENAL

DOADOR RENAL INFANTIL

DIURESE PRESENTE

IMPLANTE URETERAL

Lich-Gregoir (MacKinnon)

IMPLANTE URETERAL

IMPLANTE URETERAL

bull OUTRAS TEacuteCNICAS DE URETERONEOCISTOSTOMIA

ndash Politano-Leadbetter

ndash Taniguch

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

bull DIRETAS

bull Cushing

bull D mellitus bull GastriteUGD

bull Pancreatite

bull Mielodepressatildeo

bull Nefrotoxicidade

bull Hepatotoxicidade

bull Alteraccedilatildeo comportamental

bull Catarata

bull Necrose oacutessea

bullINDIRETAS

bull Infecccedilotildees

- Fungos

- Bacteacuterias

- Viacuterus

- Parasitas

bull Neoplasias

Kidney transplant recipients are more likely to develop cancer than age-matched subjects in the general population and patients wait-listed for deceased donor renal transplantation ( Kasiske et al 2004)

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

Complicaccedilatildeo imunoloacutegica

Complicaccedilotildees vasculares

bull Estenose de arteacuteria renal 17

bull Trombose de arteacuteria renal 17

bull Trombose de veia renal 14

bull Linfocele 12

Risaliti A et all G Ital Nefrol 2004

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 8: Aula Transplante Renal

IMPLANTE VASCULAR

Outra opccedilatildeo

MAIS SURPRESAS ARTEacuteRIAS MUacuteLTIPLAS

TEacuteCNICAS DE RECONSTRUCcedilAtildeO ARTERIAL DO ENXERTO

TEacuteCNICAS PARA ALONGAR VEIA RENAL

DOADOR RENAL INFANTIL

DIURESE PRESENTE

IMPLANTE URETERAL

Lich-Gregoir (MacKinnon)

IMPLANTE URETERAL

IMPLANTE URETERAL

bull OUTRAS TEacuteCNICAS DE URETERONEOCISTOSTOMIA

ndash Politano-Leadbetter

ndash Taniguch

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

bull DIRETAS

bull Cushing

bull D mellitus bull GastriteUGD

bull Pancreatite

bull Mielodepressatildeo

bull Nefrotoxicidade

bull Hepatotoxicidade

bull Alteraccedilatildeo comportamental

bull Catarata

bull Necrose oacutessea

bullINDIRETAS

bull Infecccedilotildees

- Fungos

- Bacteacuterias

- Viacuterus

- Parasitas

bull Neoplasias

Kidney transplant recipients are more likely to develop cancer than age-matched subjects in the general population and patients wait-listed for deceased donor renal transplantation ( Kasiske et al 2004)

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

Complicaccedilatildeo imunoloacutegica

Complicaccedilotildees vasculares

bull Estenose de arteacuteria renal 17

bull Trombose de arteacuteria renal 17

bull Trombose de veia renal 14

bull Linfocele 12

Risaliti A et all G Ital Nefrol 2004

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 9: Aula Transplante Renal

MAIS SURPRESAS ARTEacuteRIAS MUacuteLTIPLAS

TEacuteCNICAS DE RECONSTRUCcedilAtildeO ARTERIAL DO ENXERTO

TEacuteCNICAS PARA ALONGAR VEIA RENAL

DOADOR RENAL INFANTIL

DIURESE PRESENTE

IMPLANTE URETERAL

Lich-Gregoir (MacKinnon)

IMPLANTE URETERAL

IMPLANTE URETERAL

bull OUTRAS TEacuteCNICAS DE URETERONEOCISTOSTOMIA

ndash Politano-Leadbetter

ndash Taniguch

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

bull DIRETAS

bull Cushing

bull D mellitus bull GastriteUGD

bull Pancreatite

bull Mielodepressatildeo

bull Nefrotoxicidade

bull Hepatotoxicidade

bull Alteraccedilatildeo comportamental

bull Catarata

bull Necrose oacutessea

bullINDIRETAS

bull Infecccedilotildees

- Fungos

- Bacteacuterias

- Viacuterus

- Parasitas

bull Neoplasias

Kidney transplant recipients are more likely to develop cancer than age-matched subjects in the general population and patients wait-listed for deceased donor renal transplantation ( Kasiske et al 2004)

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

Complicaccedilatildeo imunoloacutegica

Complicaccedilotildees vasculares

bull Estenose de arteacuteria renal 17

bull Trombose de arteacuteria renal 17

bull Trombose de veia renal 14

bull Linfocele 12

Risaliti A et all G Ital Nefrol 2004

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 10: Aula Transplante Renal

TEacuteCNICAS PARA ALONGAR VEIA RENAL

DOADOR RENAL INFANTIL

DIURESE PRESENTE

IMPLANTE URETERAL

Lich-Gregoir (MacKinnon)

IMPLANTE URETERAL

IMPLANTE URETERAL

bull OUTRAS TEacuteCNICAS DE URETERONEOCISTOSTOMIA

ndash Politano-Leadbetter

ndash Taniguch

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

bull DIRETAS

bull Cushing

bull D mellitus bull GastriteUGD

bull Pancreatite

bull Mielodepressatildeo

bull Nefrotoxicidade

bull Hepatotoxicidade

bull Alteraccedilatildeo comportamental

bull Catarata

bull Necrose oacutessea

bullINDIRETAS

bull Infecccedilotildees

- Fungos

- Bacteacuterias

- Viacuterus

- Parasitas

bull Neoplasias

Kidney transplant recipients are more likely to develop cancer than age-matched subjects in the general population and patients wait-listed for deceased donor renal transplantation ( Kasiske et al 2004)

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

Complicaccedilatildeo imunoloacutegica

Complicaccedilotildees vasculares

bull Estenose de arteacuteria renal 17

bull Trombose de arteacuteria renal 17

bull Trombose de veia renal 14

bull Linfocele 12

Risaliti A et all G Ital Nefrol 2004

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 11: Aula Transplante Renal

DOADOR RENAL INFANTIL

DIURESE PRESENTE

IMPLANTE URETERAL

Lich-Gregoir (MacKinnon)

IMPLANTE URETERAL

IMPLANTE URETERAL

bull OUTRAS TEacuteCNICAS DE URETERONEOCISTOSTOMIA

ndash Politano-Leadbetter

ndash Taniguch

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

bull DIRETAS

bull Cushing

bull D mellitus bull GastriteUGD

bull Pancreatite

bull Mielodepressatildeo

bull Nefrotoxicidade

bull Hepatotoxicidade

bull Alteraccedilatildeo comportamental

bull Catarata

bull Necrose oacutessea

bullINDIRETAS

bull Infecccedilotildees

- Fungos

- Bacteacuterias

- Viacuterus

- Parasitas

bull Neoplasias

Kidney transplant recipients are more likely to develop cancer than age-matched subjects in the general population and patients wait-listed for deceased donor renal transplantation ( Kasiske et al 2004)

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

Complicaccedilatildeo imunoloacutegica

Complicaccedilotildees vasculares

bull Estenose de arteacuteria renal 17

bull Trombose de arteacuteria renal 17

bull Trombose de veia renal 14

bull Linfocele 12

Risaliti A et all G Ital Nefrol 2004

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 12: Aula Transplante Renal

DIURESE PRESENTE

IMPLANTE URETERAL

Lich-Gregoir (MacKinnon)

IMPLANTE URETERAL

IMPLANTE URETERAL

bull OUTRAS TEacuteCNICAS DE URETERONEOCISTOSTOMIA

ndash Politano-Leadbetter

ndash Taniguch

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

bull DIRETAS

bull Cushing

bull D mellitus bull GastriteUGD

bull Pancreatite

bull Mielodepressatildeo

bull Nefrotoxicidade

bull Hepatotoxicidade

bull Alteraccedilatildeo comportamental

bull Catarata

bull Necrose oacutessea

bullINDIRETAS

bull Infecccedilotildees

- Fungos

- Bacteacuterias

- Viacuterus

- Parasitas

bull Neoplasias

Kidney transplant recipients are more likely to develop cancer than age-matched subjects in the general population and patients wait-listed for deceased donor renal transplantation ( Kasiske et al 2004)

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

Complicaccedilatildeo imunoloacutegica

Complicaccedilotildees vasculares

bull Estenose de arteacuteria renal 17

bull Trombose de arteacuteria renal 17

bull Trombose de veia renal 14

bull Linfocele 12

Risaliti A et all G Ital Nefrol 2004

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 13: Aula Transplante Renal

IMPLANTE URETERAL

Lich-Gregoir (MacKinnon)

IMPLANTE URETERAL

IMPLANTE URETERAL

bull OUTRAS TEacuteCNICAS DE URETERONEOCISTOSTOMIA

ndash Politano-Leadbetter

ndash Taniguch

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

bull DIRETAS

bull Cushing

bull D mellitus bull GastriteUGD

bull Pancreatite

bull Mielodepressatildeo

bull Nefrotoxicidade

bull Hepatotoxicidade

bull Alteraccedilatildeo comportamental

bull Catarata

bull Necrose oacutessea

bullINDIRETAS

bull Infecccedilotildees

- Fungos

- Bacteacuterias

- Viacuterus

- Parasitas

bull Neoplasias

Kidney transplant recipients are more likely to develop cancer than age-matched subjects in the general population and patients wait-listed for deceased donor renal transplantation ( Kasiske et al 2004)

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

Complicaccedilatildeo imunoloacutegica

Complicaccedilotildees vasculares

bull Estenose de arteacuteria renal 17

bull Trombose de arteacuteria renal 17

bull Trombose de veia renal 14

bull Linfocele 12

Risaliti A et all G Ital Nefrol 2004

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 14: Aula Transplante Renal

IMPLANTE URETERAL

IMPLANTE URETERAL

bull OUTRAS TEacuteCNICAS DE URETERONEOCISTOSTOMIA

ndash Politano-Leadbetter

ndash Taniguch

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

bull DIRETAS

bull Cushing

bull D mellitus bull GastriteUGD

bull Pancreatite

bull Mielodepressatildeo

bull Nefrotoxicidade

bull Hepatotoxicidade

bull Alteraccedilatildeo comportamental

bull Catarata

bull Necrose oacutessea

bullINDIRETAS

bull Infecccedilotildees

- Fungos

- Bacteacuterias

- Viacuterus

- Parasitas

bull Neoplasias

Kidney transplant recipients are more likely to develop cancer than age-matched subjects in the general population and patients wait-listed for deceased donor renal transplantation ( Kasiske et al 2004)

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

Complicaccedilatildeo imunoloacutegica

Complicaccedilotildees vasculares

bull Estenose de arteacuteria renal 17

bull Trombose de arteacuteria renal 17

bull Trombose de veia renal 14

bull Linfocele 12

Risaliti A et all G Ital Nefrol 2004

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 15: Aula Transplante Renal

IMPLANTE URETERAL

bull OUTRAS TEacuteCNICAS DE URETERONEOCISTOSTOMIA

ndash Politano-Leadbetter

ndash Taniguch

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

bull DIRETAS

bull Cushing

bull D mellitus bull GastriteUGD

bull Pancreatite

bull Mielodepressatildeo

bull Nefrotoxicidade

bull Hepatotoxicidade

bull Alteraccedilatildeo comportamental

bull Catarata

bull Necrose oacutessea

bullINDIRETAS

bull Infecccedilotildees

- Fungos

- Bacteacuterias

- Viacuterus

- Parasitas

bull Neoplasias

Kidney transplant recipients are more likely to develop cancer than age-matched subjects in the general population and patients wait-listed for deceased donor renal transplantation ( Kasiske et al 2004)

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

Complicaccedilatildeo imunoloacutegica

Complicaccedilotildees vasculares

bull Estenose de arteacuteria renal 17

bull Trombose de arteacuteria renal 17

bull Trombose de veia renal 14

bull Linfocele 12

Risaliti A et all G Ital Nefrol 2004

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 16: Aula Transplante Renal

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

bull DIRETAS

bull Cushing

bull D mellitus bull GastriteUGD

bull Pancreatite

bull Mielodepressatildeo

bull Nefrotoxicidade

bull Hepatotoxicidade

bull Alteraccedilatildeo comportamental

bull Catarata

bull Necrose oacutessea

bullINDIRETAS

bull Infecccedilotildees

- Fungos

- Bacteacuterias

- Viacuterus

- Parasitas

bull Neoplasias

Kidney transplant recipients are more likely to develop cancer than age-matched subjects in the general population and patients wait-listed for deceased donor renal transplantation ( Kasiske et al 2004)

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

Complicaccedilatildeo imunoloacutegica

Complicaccedilotildees vasculares

bull Estenose de arteacuteria renal 17

bull Trombose de arteacuteria renal 17

bull Trombose de veia renal 14

bull Linfocele 12

Risaliti A et all G Ital Nefrol 2004

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 17: Aula Transplante Renal

COMPLICACcedilOtildeES CLIacuteNICAS DA IMUNOSUPRESSAtildeO

Complicaccedilatildeo imunoloacutegica

Complicaccedilotildees vasculares

bull Estenose de arteacuteria renal 17

bull Trombose de arteacuteria renal 17

bull Trombose de veia renal 14

bull Linfocele 12

Risaliti A et all G Ital Nefrol 2004

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 18: Aula Transplante Renal

Complicaccedilatildeo imunoloacutegica

Complicaccedilotildees vasculares

bull Estenose de arteacuteria renal 17

bull Trombose de arteacuteria renal 17

bull Trombose de veia renal 14

bull Linfocele 12

Risaliti A et all G Ital Nefrol 2004

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 19: Aula Transplante Renal

Complicaccedilotildees vasculares

bull Estenose de arteacuteria renal 17

bull Trombose de arteacuteria renal 17

bull Trombose de veia renal 14

bull Linfocele 12

Risaliti A et all G Ital Nefrol 2004

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 20: Aula Transplante Renal

Complicaccedilatildeo vascular

Surgical intervention for transplant renal artery stenosis is difficult with a significant risk of technical failure and percutaneous transluminal angioplasty with or without endoluminal stent placement has become the initial treatment of choice ( Nicita et al 1998 )

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 21: Aula Transplante Renal

COMPLICACcedilOtildeES UROLOGICAS

Because the renal transplant is denervated the patient will not experience typical renal colic and the diagnosis is suspected when renal function suddenly deteriorates or transplant pyelonephritis occurs

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 22: Aula Transplante Renal

COMPLICACcedilOtildeES UROLOacuteGICAS

bull ITU 285

bull Fiacutestula urinaacuteria 67

bull Estenose ureteral 14

bull Tratamento

ndash Minimamente invasivo

ndash Re-implante ureteral

Burmeister D et all Urologe A 2006

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 23: Aula Transplante Renal

CAUSAS DE PERDA DO ENXERTO ()

Rejeiccedilatildeo hiperaguda

15

Rejeiccedilatildeo aguda

150

Rejeiccedilatildeo crocircnica

210

Causa vascular

136

Causa uroloacutegica

00

Recidiva da doenccedila de base

28

Oacutebito c rim funcionante

352

Rutura renal 07

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 24: Aula Transplante Renal

Unadjusted Graft and Patient Survival at 3 Months 1 Year 3 Years 5 Years and 10 YearsSurvival ()

Source OPTNSRTR Data as of May 1 2008

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 25: Aula Transplante Renal

bull Urologe A 2006 Jan45(1)25-31 Review German[Urological complications after kidney transplantation]

bull [Article in German] bull Burmeister D Noster M Kram W Kundt G Seiter H bull Urologische Klinik und Poliklinik Universitaumlt E-Heydemann-Strasse 6 18055

Rostock dirkburmeistermeduni-rostockde bull Abstract bull Between August 1981 and May 2005 1065 consecutive kidney transplants were

performed at our center 393 patients (369) developed urological complications in the first 60 postoperative days Urinary tract infections occurred in 285 of all patients The major urological problems seen were urinary leakage and ureteral obstruction in 62 and 14 of the patients Two grafts were lost due to severe urinary leakage No patient death occurred due to urological complications The incidence of urological complications is mainly influenced by the surgical procedure of organ retrieval and ureteroneocystostomy With double-J stenting of the extravesical ureteroneocystostomy we observed a significantly lower rate of urinary leakage but a higher rate of urinary tract infections in our series Early diagnosis and treatment of urological complications may prevent further morbidity of our transplant patients

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications

Page 26: Aula Transplante Renal

bull G Ital Nefrol 2004 Jan-Feb21 Suppl 26S43-7 bull [Surgical complications after kidney transplantation] bull [Article in Italian] bull Risaliti A Sainz-Barriga M Baccarani U Adani GL Montanaro D Gropuzzo M Tullissi

P Boscutti G Lorenzin D Mioni G Bresadola F bull Unita Trapianti Clinica Chirurgica dellUniversita degli Studi di Udine PUGD

arisalitimeduniudit bull Abstract bull Chronic renal failure needs substitutive treatment such as haemodialysis and

peritoneal dialysis for the patient to survive Kidney transplantation (KTx) improves survival of the patient with chronic renal failure Since the first KTx performed by Merrill in Boston in 1959 advances in medical therapy immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient We present a review of the incidence diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002 Vascular complications represent 5-10 of postoperative complications Our experience showed an incidence of 17 renal artery thrombosis 14 renal vein thrombosis 17 renal artery stenosis 14 arterial rupture due to fungal arteritis 07 spontaneous graft ruptures and 12 lymphoceles Urological complications account for 10-15 of postoperative complications In our series we found an incidence of 74 urinary leakage 27 urinary obstruction and 3 urinary reflux Gastrointestinal complications represent 16 of postoperative complications Our series showed 1 pancreatitis with an overall mortality of 33 and an incidence of 17 intestinal perforations Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications