anticorpos e sistema complemento

8/16/2019 Anticorpos e Sistema Complemento

http://slidepdf.com/reader/full/anticorpos-e-sistema-complemento 1/10

ABBAS 4 E 5 EDGAR MACÁRIOMEDUFES 96

ANTICORPOS: ONTOGENIA E FUNÇÕES

Os antic!"s s# $%ic"!t&'nas ci!c(%ant&s "!)(*i)as &+ !&s"sta ,

&-"si.# a ant'$&ns n# "!/"!is0 Os antic!"s )as c1%(%as B & as+%1c(%as )& M2C & s TCR )as c1%(%as T s# as +%1c(%as c3a& )a!&s"sta i+(n& a)a"tatia "a!a a %i$a.# a ant'$&ns0 T)as as +%1c(%as(& t+ ca"aci)a)& )& !&cn3&c&! ant'$&n7 t+ "t&ncia% "a"&% )&n&(t!a%i*a.# )& ant'$&ns0

Os antic!"s &st# "!&s&nt&s &+ 8(i)s i%/$ics "%as+a7 %in;a7 %<!i+aI7sa%ia= & na s("&!;'ci& )& a%$(+as c1%(%as %in;i)&s %in;/cit B7 ;a$/cit+nn(c%&a!7 N>7 +ast/cits=0

Os antic!"s ")&+ &sta! "!&s&nt&s s )(as ;!+as: %i$a)s a

+&+!anas na s("&!;'ci& )& %in;/cits B7 s&n) c3a+a)s )& !&c&"t!&s)& c1%(%as B ( i+(n$%(%inas )& s("&!;'ci&? ( c+ antic!"ss&c!&ta)s !&si)&nt&s na ci!c(%a.#7 ns t&ci)s & nas +(csas0 A ;!+as&c!&ta)a n# t&+ a ca()a cit"%as+<ticas & a ca)&ia )& a+in<ci)s3i)!;/ics 1 "&!)i)a0 S(a ;(n.# 1 a )& &%i+ina! ant'$&n7 s <!ias;!+as:

• N&(t!a%i*a.# )& +ic!@!$anis+s ( "!)(ts +ic!ians t/-ics• Atia.# ) sist&+a c+"%&+&nt• O"sni*a.# )& "at/$&ns7 a(+&ntan) a ;a$cits&• Citt-i)a)& +&)ia)a "! c1%(%as )&"&n)&nt&s )& antic!"s

ADCC=7 &+ (& antic!"s +a!ca+ c1%(%as in;&cta)as "a!a s(a %is&"! c1%(%as ) sist&+a i+(n& inat

• Atia.# )& +ast/cits +&)ia)a "! antic!"s7 (& &%i+ina &!+&s"a!asitas

As c1%(%as B &-"!&ssa+ a ;!+a int&$!a% )& antic!" anc!a)a na+&+!ana7 (& at(a c+ s&(s !&c&"t!&s )& ant'$&n BCR=0 A"/s&-"si.# a ant'$&n7 a c1%(%a B na& s& atia & s& )i;&!&ncia &+"%as+/cits s&c!&t!&s )& ant'$&ns0




ESTRUTURAA &%(ci)a.# )a &st!(t(!a ;i "ss'&% c+ a )&sc&!ta )& (& "aci&nt&sc+ +i&%+a +%ti"% t(+! )& "%as+/cits +nc%nais= t&n)&+ aa"!&s&nta! $!an)&s (anti)a)&s )& antic!"s +nc%nais ) c%n&n&"%<sic n san$(& & na (!ina0 T!a)icina%+&nt&7 as "!t&'nas

"%as+<ticas s# s&"a!a)as &+ a%(+ina & $%(%inas0Estas ")&+ ain)a s&! s&"a!a)as "! &st&!n %t &+ an)as7

s&n) a t&!c&i!a +ais %&& a )as $a+a$%(%inas7 n)& s&&ncnt!a+ +ai!ia )as i+(n$%(%inas I$=0

A &st!(t(!a <sica )& t)as as I$ cnsist& )& )(asca)&ias "%i"&"t')icas "&sa)as i)nticas & )(as

ca)&ias "%i"&"t')icas %&&s i)nticas (ni)as "!"nt&s )iss(%;&t0 As ca)&ias %&&s & "&sa)as cnt+s1!i& )& (ni)a)&s 3+/%$as !&"&ti)as (& s&

)!a+ in)&"&n)&nt&+&nt& &+ (+a ;!+a $%(%a!c3a+a)a domínio Ig c+ & 2=7 ;!+a)a "!

;%3as @"!&$(&a)as0 A superfamília Ig !&n& +%1c(%asc+ )+'nis I$ & inc%(&+ TCR7 M2C )& c%ass& I7 CD4c!!&c&"t! )& %in;/cits T=7 CDH !&c&"t!

c&sti+(%a)! )& %in;/cit T= & ICAM@ +%1c(%a )& a)&s#=0

As ca)&ias %&&s & "&sa)as s# ;!+a)as "!regiões aminoterminais variáveis (V)& "! !&$iJ&s carboxiterminais

constantes (C)0 As !&$iJ&s s& %i$a+ aant'$&n & )&t&!+ina+ a &s"&ciKci)a)& )aI$ & as !&$iJ&s C s# !&s"ns<&is "&%as"!"!i&)a)&s ;'sic@('+icas & +&)&ia+ as;(n.J&s &;&t!as )as I$0 Nas ca)&ias %&&s7 a!&$i# 1 c+"sta "! (+ )+'ni I$ = & a!&$i# C "! (+ )+'ni I$ C=0 Nasca)&ias "&sa)as7 a !&$i# 1 c+"sta"! (+ )+'ni I$ 2= & a !&$i# C7 "! L( 4 )+'nis I$ C27 C27 C2L7 C24=0 As

!&$iJ&s & 2 "a!tici"a+ )!&cn3&ci+&nt & %i$a.# a ant'$&n7 a "ass

(& s )+'nis I$ )a!&$i# C )a

ca)&ia"&sa)a s#!&s"ns<&is "&%a int&!a.# c+

(t!as +%1c(%as &;&t!as & c1%(%as )sist&+a i+(n&0 As ca)&ias %&& & "&sa)a7

&+ c+ as )(as ca)&ias "&sa)as7 s&

+ant+ (ni)as "! "nt&s )& )iss(%;&t &nt!&!&s')(s )& cist&'na0




(an) t!ata)as c+ "!t&as&s7 as I$ s# s&"a!a)as &+ "!.J&s7 )&ac!) c+ a &n*i+a (sa)a0 A "a"a'na c%ia as +%1c(%as )& I$G &+ )(as+%1c(%as i$(ais7 (& cnt+ a ca)&ia %&& int&i!a & C= & "a!t& )a"&sa)a 2 & C2=7 & (+a c+"sta "! )is "&"t')&s i)ntics %i$a)s"! "nt&s )& )iss(%;&t0 Os )is s&$+&nts i)ntics +ant+ a

ca"aci)a)& )& %i$a.# a ant'$&n7 s&n) c3a+a)as )& porção Fab;!a$+&nt )& %i$a.# a ant'$&n=0 O t&!c&i! ;!a$+&nt a"!&s&ntat&n)ncia a s& c!ista%i*a!7 s&n) )&n+ina)a porção Fc "!.#c!ista%i*<&%=0 (an) 1 (sa)a a "&"sina7 a +%1c(%a )& I$G 1 s&"a!a)a&+ (+ ;!a$+&nt )& %i$a.# a ant'$&n c3a+a) F(ab)!7 s&+ a;&ta! a)!a)i.a & as "nt&s )iss(%;&t int&!ca)&ias0

R&$iJ&s a!i<&isE-ist&+ regiões "ipervariáveis nas a%.as )as %+inas )s )+'nis )as ca)&ias "&sa)as & %&&s )as I$0 Os t!s s&$+&nts 3i"&!a!i<&is )aca)&ia %&& (nt c+ (t!s t!s s&$+&nts 3i"&!a!i<&is )a ca)&ia"&sa)a s& (n&+ c+ )&)s )& +#s "stas & ;!+a+ a s("&!;'ci& )&%i$a.# a ant'$&n0 Assi+7 as !&$iJ&s 3i"&!a!i<&is s# c3a+a)asta+1+ )& regiões determinantes de complementariedade (C#$)0

R&$iJ&s cnstant&sAs c%ass&s & s(c%ass&s )& i+(n$%(%inas s# )&t&!+ina)as c+ as&

nas )i;&!&n.as &st!(t(!ais )& s(as !&$iJ&s C )a ca)&ia "&sa)a0 Assi+7 I$G"ss(&+ 4 s(c%ass&s I$G7 I$G7 I$GL & I$G4= c+ 4 ca)&ias "&sa)as)i;&!&nt&s &nt!& si? I$A "ss(i )(as s(c%ass&s I$A & I$A= & ain)a n#;!a+ )&sc!itas s(c%ass&s "a!a I$E7 I$M & I$D0 Esta a!iai%i)a)& nasc%ass&s )& i+(n$%(%inas 1 )&n+ina)a variação isotípica0 As ca)&ias"&sa)as s# )&si$na)as "&%a %&t!a ) a%;a&t $!&$ (& c!!&s"n)& ais/ti" ) antic!"0 As !&$iJ&s C )a ca)&ia "&sa)a )& t)as as +%1c(%as)& antic!" )& (+ is/ti" ( s(ti" a"!&s&nta+7 &ss&ncia%+&nt&7 a+&s+a s&(ncia )& a+in<ci)s0 Essa s&(ncia7 assi+7 1 )i;&!&nt& &+antic!"s )& (t!s is/ti"s ( s(ti"s0 E+ 3(+ans7 as !&$iJ&s C )&

I$M & I$E cnt+ 4 )+'nis I$ s&(&nciais7 a "ass (& I$A7I$D & I$G "ss(&+ a"&nas L )+'nis I$ nas !&$iJ&s C0

Di;&!&nt&s is/ti"s & s(ti"s "ss(&+ ;(n.J&s )i;&!&nt&s7)&t&!+ina)as "&%a %i$a.# )as !&$iJ&s C )a ca)&ia "&sa)a a

!&c&"t!&s )& Fc a c1%(%as c+ ;a$/cits7 c1%(%as N> & +ast/cits & a"!t&'nas "%as+<ticas7 c+ as ) c+"%&+&nt0 As )i;&!&nt&s ;(n.J&s&;&t!as s# )&i) ,s )i;&!&n.as &nt!& as !&$iJ&s C0 A%1+ )iss7 asregiões de dobradiça "&!+it&+ (& antic!" s& %i$(& a )(as+%1c(%as )& ant'$&ns s&"a!a)as "! )istncias a!i<&is0 Essas

!&$iJ&s )& )!a)i.a "&!+it&+ a +i+&nta.# in)&"&n)&nt& )s s'tis)& %i$a.# a ant'$&n &+ !&%a.# a !&stant& )a +%1c(%a0 A




IGAÇO ENTRE ANTICORPOS E ANTQGENOSU+ antígeno 1 (a%(&! s(stncia (& ")& s&! &s"&ciKca+&nt& %i$a)aa (+a +%1c(%a )& antic!" ( !&c&"t! )& %in;/cits T0 Os antic!"s!&cn3&c&+ s(stncias s%&is7 c+ +&ta/%its int&!+&)i<!issi+"%&s7 a.ca!&s7 %i"')&s7 a(taci)&s7 3!+nis7 ca!i)!atsc+"%&-s7 ;s;%i"')is7 <ci)s n(c%&ics & "!t&'nas0 R&c&"t!&s )&%in;/cits T !&cn3&c&+ a"&nas "&"t')&s asscia)s a +%1c(%as )& M2C0

Ant'$&ns (& )&s&nca)&ia+ !&s"sta i+(n%/$ica s# c3a+a)simungenos0 S+&nt& +ac!+%1c(%as s# ca"a*&s )& &sti+(%a!%in;/cits B7 inician) !&s"stas i+(n&s 3(+!ais7 (+a &* (& a atia.#)&ssa c1%(%a !&(&! a %i$a.# c!(*a)a )& +%ti"%s !&c&"t!&s )& ant'$&nc+ s s&(s !&s"&ctis ant'$&ns "!t&ics7 "a!a &sti+(%a.# )&%in;/cits T 3&%"&!0

Os determinantes ( epítopos s# !&$iJ&s )s ant'$&ns as (ais s&%i$a+ as I$0 Os )&t&!+inant&s ")&+ s&! s!&"sts (an) 3<i+"&)i+&nt &st1!ic= & n# s!&"sts0 A %i$a.# )& (+a I$ a ant'$&n")& &-&!c&! &;&its a%/st&!ics0 Os )&t&!+inant&s ")&+ s&! %in&a!&s7(an) s aa0 &st# &+ s&(ncia? cn;!+acinais7 (an) s aa0"assa+ a s&! (sta"sts na "!t&'na )!a)a? ( n&anti$nics7 (an)s;!&+ +)iKca.J&s "/s@sint1ticas7 c+ c%ia$&+ )& "nt&s "&"t')icas0

S& a I$ ;! +n+&!7 c+ I$E & I$G7 ")&+ 3a&! )is s'tis )& %i$a.#7(+ &+ ca)a Fa0 S& ;! )'+&!7 "&% +&ns (at! %i$a.J&s0 Na I$M"&nta+1!ica7 s# "ss'&is )&* %i$a.J&s0 As %i$a.J&s s# si+(%tn&as &

i$(ais "!(& a &s"&ciKci)a)& 1 a +&s+a7 ( s&a7 s s'tis )& %i$a.# )&ant'$&n )& (+a I$ "ss(&+ +&s+ !&cn3&ci+&nt )a ca)&ia"&"t')ica anti$nica0

A anidade 1 a ;!.a )& %i$a.# &nt& (+ nic s'ti )& c+ina.# )& (+antic!" & (+ &"'t" ) ant'$&n0 !&"!&s&nta)a "&%a constante dedissociação * d7 (& in)ica a ;aci%i)a)& )& s&"a!a.# ) c+"%&-ant'$&n@antic!" &+ s&(s cnstit(int&s0 U+a > ) ai-a in)ica +ai!aKni)a)& )& int&!a.#7 (+a &* (& +&n! cnc&nt!a.# )& ant'$&n ()& antic!" 1 n&c&ss<!ia , ;!+a.# ) c+"%&-0 Os ant'$&ns

"%ia%&nt&s a"!&s&nta+ +ais )& (+a c/"ia ) )&t&!+inant&0 Assi+7 a;!.a )& %i$a.# ) antic!" a ant'$&n )&& cnsi)&!a! a int&!a.# )&t)s s s'tis a t)s s &"'t"s )is"n'&is0 U+a I$M )& ai-a aKni)a)&1 ca"a* )& s& %i$a! a ant'$&n c+ a%ta ai)&* "!(& as int&!a.J&s )&ai-a aKni)a)& s& s+a+0

REAÇÕES ENTRE ESTRUTURA E FUNÇO NAS MOCUAS DEANTICORPO

0 Es"&ciKci)a)&: s antic!"s s# ca"a*&s )& )i;&!&ncia! (+a nicas(stit(i.# a+in<ci)a (& "(c int&!;&!& na &st!(t(!as&c(n)<!ia0 Cnt()7 a%$(ns antic!"s "!)(*i)s cnt!a (+




ant'$&n ")&+ s& %i$a! a ant'$&ns )i;&!&nt&s7 +as&st!(t(!a%+&nt& si+i%a!&s7 ;&n+&n cn3&ci) c+ reaçãocru+ada7 cn)i.# ;a!&ci)a "! sit(a.J&s )& 3+&stas&)&s;a!<&%0 Antic!"s nat(!ais s# &s"&c'Kcs "a!a (+ ant'$&n+&s+ s&+ &-"si.# "!1ia0 A nat(!&*a )a %i$a.# 1 &s"&c'Kca7 n

+)&% c3a&@;&c3a)(!a00 Di&!si)a)&: 1 $&!a)a "&%a !&c+ina.# D=X )& %in;/cits7 (&

)&t&!+ina+ )i;&!&nt&s !&$iJ&s )as ca)&ias %&& & "&sa)a7 assi+c+ "&%a a)i.# )& n(c%&t')&s )(!ant& "!c&ss )&!&c+ina.#0

L0 Mat(!a.# )& aKni)a)&: c!!& +(ta.# s+<tica "! +()an.ass(tis ns s&$+&nts )as i+(n$%(%inas )(!ant&s as !&s"stasi+(n&s 3(+!ais )&"&n)&nt&s )& %in;/cits T a ant'$&ns "!t&ics0Os %in;/cits "!)(t!&s )& tais I$ s;!&+ s&%&.# & "assa+ a s&! c%n& )+inant&0

40 Int&!a.# )a "!.# Fc a !&c&"t!&s )& Fc FcR= &s"&c'Kcs &+c1%(%as: n&(t!/K%s & +ac!/;a$s !&cn3&c&+ a "!.# Fc )a I$G%i$a)a a +ic!@!$anis+s7 (& s;!&+ ;a$cits&0 Mast/cits!&cn3&c&+ a "!.# Fc )& I$E & )&s$!an(%a+0

50 Atia.# )a ia c%<ssica ) sist&+a c+"%&+&nt: )isc(ti)a +aisa)iant&

60 M()an.a )& c%ass& ( )& is/ti": a"/s &sti+(%a.#7 (+ nic c%n&)& %in;/cits B ")& "!)(*i! antic!"s )& )i;&!&nt&s is/ti"s (&7ain)a assi+7 a"!&s&nta+ )+'nis i)ntics &7 "!tant7&s"&ciKci)a)& i)ntica a ant'$&n0 Iss 1 i+"!tant& "!(& s

is/ti"s & s(ti"s a$!a sint&ti*a)s a%1+ )& I$M & I$D= s# +aisa)&(a)s , &%i+ina.# ) ant'$&n7 "is ca)a is/ti" )&s&+"&n3a(+ )i;&!&nt& cn(nt )& ;(n.J&s &;&t!as0

Y0 R&$iJ&s C )a ca)&ia "&sa)a )as I$ ta+1+ )&t&!+ina+ a)ist!i(i.# t&ci)(a% )as i+(n$%(%inas0 O (& )&t&!+ina a)ist!i(i.# s# s +&canis+s atis )as I$: t!;%ast t&+"!t&'nas s !&c&"t!&s FcRn= (& !&cn3&c&+ "!.# Fc )a I$G7 &!&a%i*a t!ans"!t& )a "%ac&nta "a!a ;&t0 A I$A s& %i$a a (+!&c&"t! ) %a) )a +at!i* & "assa

atia+&nt& "!t!anscits&"a!a +(c &s&c!&.J&s




ISZTIPOS0 I$A

i0 S(ti"s I$A & I$Aii0 Ca)&ias 2 [ & [iii0 F!+a s&c!&ta)a +n+1!ica7 )i+1!ica ( t!i+1!ica

i0 R&s"ns<&% "! i+(ni)a)& )as +(csas0 N&(t!a%i*a.# )&ant'$&ns7 s&a+ "at/$&ns7 s&a cnt!%& )& act1!iasc+&nsais0 Cnt!%& )& +ic!ita0 acina !a% )a "/%iSain= t&+ c+ ;(n.# &sti+(%a! a "!)(.# )& I$A&s"&c'Kca0 S& %i$a a (+ !&c&"t! ) %a) )a +at!i* & "assaatia+&nt& "! t!anscits& "a!a +(c & s&c!&.J&s0

0 I$Di0 N# t&+ s(ti"sii0 Ca)&ia 2 iii0 Bai-s n'&is n s!

i0 R&c&"t!a )& ant'$&ns )as c1%(%as B na&L0 I$Ei0 N# t&+ s(ti"sii0 Ca)&ia 2 \iii0 F!+a s&c!&ta)a +n+1!icai0 R&s"ns<&% "&%a 3i"&!s&nsii%i)a)& i+&)iata0 En%i)a &+

!&a.J&s a%1!$icas & &+ in;&c.J&s "! 3&%+ints040 I$G

i0 S(ti"s I$G@4ii0 Ca)&ias 2 ] 7 7 L & 4=iii0 F!+a s&c!&ta)a +n+1!icai0 R&s"ns<&% "&%a "sni*a.#7 atia.# ) sist&+a

c+"%&+&nt7 i+(ni)a)& n&nata% ca"aci)a)& )&at!a&ssa! a a!!&i!a "%ac&nt<!ia=7 inii.# "! ;&&)ac^ )asc1%(%as B7 )&s$!an(%a.# )& c+"n&nt&s citt/-ics c+!&c&"t! FcR )& I$G c1%(%as N>=0 , citotoxicidademediada por c-lulas dependentes de anticorpos(,#CC) 1 (+ +&canis+ )& )&;&sa i+(n& +&)ia)a "!c1%(%as n (a% (+a c1%(%a &;&t!a ) sist&+a i+(n&"!ca a %is& atia+&nt& )& (+a c1%(%a a% (& s;!&("sni*a.#7 s&n) +&)ia)a "! c1%(%as N>7 +ac!/;a$s7n&(t!/K%s & &sin/K%s0 Mac!/;a$ & c1%(%as N> t+!&c&"t! c3a+a) Fc]RIIIA ] ca)&ia "&sa)a )& I$G7 Fc )&"!.# Fc7 R )& !&c&"t!=: ac"%a+&nt ) c+"%&-ant'$&n@I$ a !&c&"t! atia a "!)(.# & s&c!&.# )&citcinas IFN@]= &+ c+ a %i&!a.# ) cnt&) )s$!n(%s7 s (ais +&)&ia+ a +!t& c&%(%a!0 As c1%(%as N>7(an) atia)as7 %i&!a+ $!n(%s cnt&n) perforinas7(& a!&+ "!s nas c1%(%as "a!a a &nt!a)a )& gran+imas7&n*i+as (& inicia+ a a""ts& nas c1%(%as@a%0 A%1+

)iss7 c1%(%as N> %i&!a+ catepsina .7 (& as "!t&$&+ )as&n*i+as %i&!a)as0




As !&s"stas n# s# c+"a!ti%3a)as (an) ant'$&ns s# a)+inist!a)s"! ia "a!&nt&!a%7 "is at(a+ &s"&ciKca+&nt& n %ca% n)& ;!a+c%ca)s0

ATIAÇO DO COMPEMENTOO sist&+a c+"%&+&nt 1 c+"st "! <!ias "!t&'nas "%as+<ticas (&t!aa%3a+ (ntas na "sni*a.# )& +ic!@!$anis+s7 na "!+.# )!&c!(ta+&nt )& ;a$/cits "a!a s'ti )& in;&c.# &7 &+ a%$(ns cass7 na+!t& )i!&ta ) "at/$&n0 A atia.# s& )< "! L ias:

0 A via clássica 1 (+ )s "!inci"ais +&canis+s &;&t!&s ) !a.3(+!a% )as !&s"stas i+(n&s a)a"tatias0 T&+ "a!tici"a.# )& I$M

& I$G7 ( s&a7 1 )&"&n)&nt& )as "!.J&s Fc )& I$M & I$G "a!a (&s c+"n&nt&s int&!aa+ c+ (t!as "!t&'nas ) c+"%&+&nt00 A via alternativa 1 +ais anti$a7 K%$&n&tica+&nt&7 (& a c%<ssica0

)&s&nca)&a)a (an) a "!t&'na CL !&cn3&c& )i!&ta+&nt&c&!tas &st!(t(!as )a s("&!;'ci& +ic!iana0 R&%acina@s& c+ ai+(ni)a)& inata & in)&"&n)& )& antic!"0

L0 A vias das lectinas 1 )&s&nca)&a)a "&%a "!t&'na "%as+<ticac3a+a)a %&ctina %i$ant& )& +ans& MB=7 "!t&'na ci!c(%ant& (&!&cn3&c& !&s')(s t&!+inais )& +ans& "!&s&nt&s &+$%ic"!t&'nas & $%ic%i"')is +ic!ians0

A%$(+as +%1c(%as ) c+"%&+&nt ")&+ t&! atii)a)& )& "sni*a.#7;a!&c&n) atii)a)& )a !&s"sta inata0 A%t&!natia & %&ctina a$&+"!i+&i! "!(& n# )&"&n)&+ )& antic!" & )&"is &+ a c%<ssica7 a"/s+nta$&+ )a !&s"sta a)a"tatia0

O !&cn3&ci+&nt )& +ic!@!$anis+s "! (a%(&! (+a )as t!s ias )sist&+a c+"%&+&nt !&s(%ta n !&c!(ta+&nt s&(&ncia% & na +nta$&+)& (t!as "!t&'nas )&st& sist&+a &+ c+"%&-s )& "!t&as&s0 U+ )&st&sc+"%&-s7 a C/ convertase7 c%ia a "!t&'na CL &+ CLa & CL7 &stas&n) (+a "snina (& "!+& a ;a$cits& )& +ic!@!$anis+s0 A

+%1c(%a CL s& %i$a , s("&!;'ci& +ic!iana n)& a ia ) sist&+ac+"%&+&nt ;i atia)a0 A +%1c(%a CLa 1 %i&!a)a & &sti+(%a ain8a+a.# "! a$i! c+ (i+it<tic "a!a n&(t!/K%s0 O CL s& %i$a a(t!s c+"n&nt&s ) sist&+a c+"%&+&nt7 ;!+an) (+a "!t&as&c3a+a)a C0 convertase7 (& c%ia C5 &+ C5a & C50 O ;!a$+&nt C5a7a%1+ )& s&! (i+it<tic7 in)(* a%t&!a.J&s ns ass san$('n&s7 %&an)a &-t!aasa+&nt )& "!t&'nas "%as+<ticas & 8(i)s ns s'tis )&in;&c.#7 a%1+ )& "!+&! a &-"!&ss# )& P@s&%&ctina7 (& "!+& a%i$a.# )& n&(t!/K%s0 O ;!a$+&nt C5 "&!+an&c& %i$a) , +&+!ana+ic!iana & inicia a ;!+a.# )& (+ c+"%&- "!t&ic ) sist&+a

c+"%&+&nt ;!+a) "! C67 CY7 CH & C9=0 Ess& c+"%&- "!t&ic




;!+a complexo de ata1ue 2 membrana (3,C)7 (& "!+& a %is&"! c3(& s+/tic )& c1%(%as &+ (& c+"%&+&nt 1 atia)0

Cascata )& ca$(%a.#: ")&+ t&! )(as ;(n.J&s <sicas0 E+ sit(a.J&s )&3+&stas&s &st# inatias n "%as+a7 assi+ c+ "!t&'nas )&

ca$(%a.#0 (an) 3< &-t!aasa+&nt )&ssas +%1c(%as "a!a t&ci)73< atia.# & int&!a.# &nt& si0 S# "!t&'nas c+ atii)a)& cata%'tica &+cascata0

anticorpos e sistema complemento

Documents