1.genes não corinebacterineae

1.Genes não Corinebacterineae

•Específicos de C. pseudotuberculosis

•Transferidos de outros clados

txid85007[Orgn] AND chromosome[Replicon Type] AND complete[PROP] AND reference[PROP]

110,052 seqs 26 genomes:Corynebacterium (7)Mycobacterium (17)Rhodococcus (1)Nocardia (1)

tBLASTnCpCDS

317 NH-CpCDS

tBLASTnOther txid85007

310 NH-CpCDS

RGMG

tBLASTnUniprotKB + nr30 CpCDS26 distinct

C. pseudotuberculosis:SMase DSerine protease precursor

280 “no hit”

YP_946759.1 putative CAAX amino terminal protease family proteinYP_173716.1 hypothetical protein ABC0212NP_781294.1 regulatory protein (padR family)YP_001107303.1 similar to superfamily I DNA and RNA helicases and helicase subunitsYP_056299.1 conserved phage-associated proteinYP_056299.1 conserved phage-associated proteinYP_056300.1 hypothetical phage-associated proteinYP_001813295.1 PTS system, fructose-specific IIBC componentYP_001159253.1 protein of unknown function DUF181YP_001159259.1 hypothetical protein Strop_2434YP_001537420.1 Lantibiotic dehydratase domain proteinYP_001159257.1 hypothetical protein Strop_2432ZP_01042386.1 Secreted subtilisin-like peptidaseYP_084726.1 CAAX amino terminal protease family proteinNP_969614.1 nitrite reductase periplasmic cytochrome c552YP_630432.1 putative cytochrome c nitrite reductase, small subunit NrfHXP_001319569.1 viral A-type inclusion protein, putativegb|AAA67924.1 serine proteinase precursor**YP_907156.1 hypothetical protein MUL_3536ZP_01665177.1 transcriptional antiterminator, BglGZP_01170419.1 nucleoside transporterYP_001107303.1 similar to superfamily I DNA and RNA helicases and helicase subunitsZP_01665177.1 transcriptional antiterminator, BglGZP_02044925.1 hypothetical protein ACTODO_01808ZP_02044932.1 hypothetical protein ACTODO_01815ZP_02044932.1 hypothetical protein ACTODO_01815ZP_02044932.1 hypothetical protein ACTODO_01815ZP_01042386.1 Secreted subtilisin-like peptidaseZP_00651843.1 hypothetical protein XfasaDRAFT_1247ZP_01407840.1 hypothetical protein SpneT_02001734

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ActinobacteriaProteobacteriaProteobacteriaActinobacteriaActinobacteria FirmicutesActinobacteria Firmicutes Chloroflexi Proteo Eukaryotes/InsectaActinobacteriaFirmicutes Proteo Bacterioidetes SpirochaetesActinobacteria Firmicutes Proteo Archaea Cyanobacteria Bacterioides/ChlorobiActinobacteriaActinobacteriaActinobacteria FirmicutesProteobacteria Actinobacteria Chloroflexi Deinococcus/ThermusProteobacteriaProteobacteria Planctomycetes Chlamidiae/Verrucomicrobia groupFirmicutes Bacterioides/ChlorobiProteobacteria Planctomycetes Chlamidiae/Verrucomicrobia groupBacterioides/Chlorobi Firmicutes SynergistetesEukaryotes/ProtozoaFirmicutesActinobacteria ProteobacteriaFirmicutes Proteobacteria ActinobacteriaFirmicutes Proteobacteria ActinobacteriaActinobacteriaFirmicutes Proteobacteria ActinobacteriaActinobacteria Cyanobacteria Firmicutes Proteobacteria Fusobacteria Chlamidiae/Verrucomicrobia groupActinobacteria Firmicutes Spirochaetes Bacterioides/ChlorobiActinobacteria Firmicutes Bacterioides/Chlorobi Spirochaetes Eukaryotes/generalActinobacteria Firmicutes Spirochaetes Bacterioides/Chlorobi Eukaryotes/generalProteobacteria Chloroflexi Deinococcus/ThermusActinobacteriaProteobacteriaProteobacteriaProteobacteria Actinobacteria Bacterioides/Chlorobi Eukaryotes/EmbryophytaFirmicutesFirmicutes

Hit Occurence in other clades

2.Homologia com baixa similaridade

•Caso da SMase•Matrizes PSSM para COG

•Matrizes para novos clusters Seed Linkage

(psi)tblastn

PSSM114,320 86 hits

PSSM not BLOSUM

tBLASTnnr

48 hitsPSSM not “nr”

COG

No hit

COG

Ex:Cp-V1.6830 COG0419Cp-V1.2590 COG1178

common4 hits:Not CorinebacterineaeCOG annotated

Tx85007Clusters

Cp-Draft-V1.0010

COG0697-Permeases of the drug/metabolite transporter (DMT) superfamily Nostoc sp.

COG0697

Cyanobacteria

Cp-Draft-V1.8610

COG0488- ATPase components of ABC transporters with duplicated ATPase domains Listeria

COG0488 Firmicutes

Proteobacteria

Cp-Draft-V1.15550

COG1191- DNA-directed RNA polymerase specialized sigma subunit Treponema pallidum

COG1191 Spirochaetes

Cp-Draft-V1.17210

COG1994-Zn-dependent proteases Nostoc sp.

COG1994

Cyanobacteria

From 280 putative exclusive Cp-CDS, four are found by search using the PSSM matrices, but are no-hits to nr, uniprot and cog:

Arthrobacter sp.

Bacillus clausii KSM-K16

Clostridium tetani E88

Saccharopolyspora erythraea NRRL 2338

Propionibacterium acnes



Exiguobacterium sp.

Salinispora tropica CNB-440




Idiomarina baltica OS145

Bacillus cereus E33L

Bdellovibrio bacteriovorus HD100

Myxococcus xanthus DK 1622

Trichomonas vaginalis G3

Enterococcus faecalis V583

Mycobacterium ulcerans Agy99

Thermosinus carboxydivorans

Bacillus sp. NRRL B-14911

Saccharopolyspora erythraea NRRL 2338

Thermosinus carboxydivorans

Actinomyces odontolyticus ATCC




Idiomarina baltica OS145

Xylella fastidiosa Dixon

Streptococcus pneumoniae

NC_002935 Corynebacterium diphtheriae NCTC 13129

NC_004369 Corynebacterium efficiens YS-314

NC_006958 Corynebacterium glutamicum ATCC 13032

NC_003450 Corynebacterium glutamicum ATCC 13032

NC_009342 Corynebacterium glutamicum R

NC_007164 Corynebacterium jeikeium K411

NC_010545 Corynebacterium urealyticum DSM 7109

NC_010397 Mycobacterium abscessus chromosome Chromosome, complete sequence

NC_008595 Mycobacterium avium 104

NC_002944 Mycobacterium avium subsp. paratuberculosis K-10

NC_002945 Mycobacterium bovis AF2122/97

NC_008769 Mycobacterium bovis BCG str. Pasteur 1173P2

NC_009338 Mycobacterium gilvum PYR-GCK

NC_002677 Mycobacterium leprae TN

NC_008596 Mycobacterium smegmatis str. MC2 155

NC_009077 Mycobacterium sp. JLS

NC_008705 Mycobacterium sp. KMS

NC_008146 Mycobacterium sp. MCS

NC_002755 Mycobacterium tuberculosis CDC1551

NC_009565 Mycobacterium tuberculosis F11

NC_009525 Mycobacterium tuberculosis H37Ra

NC_000962 Mycobacterium tuberculosis H37Rv

NC_008611 Mycobacterium ulcerans Agy99

NC_008726 Mycobacterium vanbaalenii PYR-1

NC_006361 Nocardia farcinica IFM 10152

NC_008268 Rhodococcus sp. RHA1

1.genes não corinebacterineae

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