PCP-Disso-v3Program developed by -Anant Ketkar, Vinay Patil and A.R. Paradkar,Dept. of Pharmaceutics,

Pune- 38, Maharashtra, India.

% Release (Average with Flux))Name of the Drug = Batch = Date = Loading Dose in mg = 0 Total no. of Readings, including 'Zero-time' reading = Done by = Diffusion Medium = RPM = Volume of Dissolution Medium (ml) = Volume of Sample removed (ml) = Dilution Factor = 1Slope of Calibration curve = 29.5900Constant of Calibration curve = 0.9990R of Calibration curve = 0.1950

Skin/Membrane used = 0 0

RESULTSSr.No. Time Avg. %R SD Avg. Time Avg. Flux (mcg/cm^2/min)

1 0.00 0.00

Bharati Vidyapeeth Deemed University, Poona College of Pharmacy,

Area for diffusion studies (cm2) =

PCP Disso v3 Extra Tools >>>

DateName of the Drug

Batch CodeDone by (Initials)

Unit used for calibration curve ####

Dissolution Medium RPM

Volume of Dissolution Medium ## Loading dose in mg ##

## Dose 1

## Dose 2Dose 3

Time inSlope 29.59

Constant 0.999Sr.No. Time Abs1 Abs2 Abs3 Abs4 Abs5 Abs6

1 0 0 0 0 0 0 0

Add values only in SKY BLUE coloured cells.It is a must to add the data in the fields marked with ##.

Total No. of Readings, including 'Zero-time' reading

Volume of Sample removed (if Fixed)

Dilution Factor (if Fixed)

Extra Tools >>>

Loading dose in mg ##

Dose 4

Dose 5Dose 6

Calculator

Unit Convertor

PCP-Disso-v3Program developed by -Anant Ketkar, Vinay Patil and A.R. Paradkar,Dept. of Pharmaceutics,

Pune- 38, Maharashtra, India.

% Release (Average) with model fittingName of the Drug = Batch = Date = Loading Dose in mg = 0 Total no. of Readings, including 'Zero-time' reading = Done by = Dissolution Medium = RPM = Volume of Dissolution Medium (ml) = Volume of Sample removed (ml) = Dilution Factor = 1Slope of Calibration curve = 29.5900Constant of Calibration curve = 0.9990R of Calibration curve = 0.1950Model Fitting (Average)-

R kZero order #DIV/0! #DIV/0! t-Table at P0.05 (Two Tails), DF=n-2:- 0T-test #NUM! #NUM!1st order #DIV/0! #DIV/0! Best fit model- #DIV/0!T-test #NUM! #NUM!Matrix #DIV/0! #DIV/0! Parameters for T-test #NUM! #NUM! Korsmeyer-Peppas Equation-Peppas #DIV/0! #DIV/0! #DIV/0!T-test #NUM! #NUM! #DIV/0!Hix.Crow. #DIV/0! #DIV/0!T-test #NUM! #NUM!RESULTS Zero 1st order Matrix Peppas Hix.Crow.

Sr.No. Time Avg. %R SD 0 0 0 0 01 -

Bharati Vidyapeeth Deemed University, Poona College of Pharmacy,

n =k =

MODEL FITTING: Residual Sum of Squares

#DIV/0!

PCP-Disso-v3Program developed by -Anant Ketkar, Vinay Patil and A.R. Paradkar,Dept. of Pharmaceutics,

Pune- 38, Maharashtra, India.

% Release (Average) with model fitting, Q(t) and t(x%)Name of the Drug = Batch = Date = Loading Dose in mg = 0 Total no. of Readings, including 'Zero-time' reading = Done by = Dissolution Medium = RPM = Volume of Dissolution Medium (ml) = Volume of Sample removed (ml) = Dilution Factor = 1Slope of Calibration curve = 29.5900Constant of Calibration curve = 0.9990R of Calibration curve = 0.1950Model Fitting (Average)- Best fit model- #DIV/0!

R k Parameters calculated by- 0Zero order #DIV/0! #DIV/0! Time Q (t) %Released t (x%)T-test #NUM! #NUM! min min

1st order #DIV/0! #DIV/0! T-test #NUM! #NUM! Matrix #DIV/0! #DIV/0! T-test #NUM! #NUM! Peppas #DIV/0! #DIV/0! T-test #NUM! #NUM! Parameters for Hix.Crow. #DIV/0! #DIV/0! Korsmeyer-Peppas Equation-T-test #NUM! #NUM! #DIV/0!t-Table at P0.05 (Two Tails), DF=n-2:- 0 #DIV/0!

RESULTS Zero 1st order Matrix Peppas Hix.Crow.Sr.No. Time Avg. %R SD 0 0 0 0 0

1 -

Bharati Vidyapeeth Deemed University, Poona College of Pharmacy,

n =k =

MODEL FITTING: Residual Sum of Squares

PCP-Disso-v3Program developed by -Anant Ketkar, Vinay Patil and A.R. Paradkar,Dept. of Pharmaceutics,

Pune- 38, Maharashtra, India.

% Release (Average) with Q(t)Name of the Drug = Batch = Date = Loading Dose in mg = 0 Total no. of Readings, including 'Zero-time' reading = Done by = Dissolution Medium = RPM = Volume of Dissolution Medium (ml) = Volume of Sample removed (ml) = Dilution Factor = 1Slope of Calibration curve = 29.5900Constant of Calibration curve = 0.9990R of Calibration curve = 0.1950%Released at Time:-

Time Q (t)min

RESULTSSr.No. Time Avg. %R SD SE-mean RSD

1

Bharati Vidyapeeth Deemed University, Poona College of Pharmacy,

PCP-Disso-v3Program developed by -Anant Ketkar, Vinay Patil and A.R. Paradkar,Dept. of Pharmaceutics,

Pune- 38, Maharashtra, India.

% Release (Average)Name of the Drug = Batch = Date = Loading Dose in mg = 0 Total no. of Readings, including 'Zero-time' reading = Done by = Dissolution Medium = RPM = Volume of Dissolution Medium (ml) = Volume of Sample removed (ml) = Dilution Factor = 1Slope of Calibration curve = 29.5900Constant of Calibration curve = 0.9990R of Calibration curve = 0.1950

RESULTSSr.No. Time Avg. %R SD SE-mean RSD

1

Bharati Vidyapeeth Deemed University, Poona College of Pharmacy,

PCP-Disso-v3Program developed by -Anant Ketkar, Vinay Patil and A.R. Paradkar,Dept. of Pharmaceutics,

Pune- 38, Maharashtra, India.

Name of the Drug = Batch = Date = Loading Dose in mg = 0 Total no. of Readings, including 'Zero-time' reading = Done by = Dissolution Medium = RPM = Volume of Dissolution Medium (ml) = Volume of Sample removed (ml) = Dilution Factor = 1Slope of Calibration curve = 29.5900Constant of Calibration curve = 0.9990R of Calibration curve = 0.1950

RESULTSSr.No. Time Avg. %R SD SE-mean Amt. (mg) % DE MDT RSD

1 0.00 0.00

Bharati Vidyapeeth Deemed University, Poona College of Pharmacy,

% Release (Average with %Dissolution Efficiency & Mean Dissolution Time)

PCP-Disso-v3Program developed by -Anant Ketkar, Vinay Patil and A.R. Paradkar,Dept. of Pharmaceutics,

Pune- 38, Maharashtra, India.

% Release (Average) & model fitting (with constraints) with Q(t) & t(x%)Name of the Drug = Batch = Date = Loading Dose in mg = 0 Total no. of Readings, including 'Zero-time' reading = Done by = Dissolution Medium = RPM = Volume of Dissolution Medium (ml) = Volume of Sample removed (ml) = Dilution Factor = 1 Constraints for model fittingSlope of Calibration curve = 29.5900 Lower (%R) = 0Constant of Calibration curve = 0.9990 Upper (%R) = 0R of Calibration curve = 0.1950Model Fitting (Average)- Best fit model- #VALUE!

R k Parameters calculated by- 0Zero order #VALUE! #VALUE! Time Q (t) %Released t (x%)T-test #NUM! #NUM! min min

1st order #VALUE! #VALUE! T-test #NUM! #NUM! Matrix #VALUE! #VALUE! T-test #NUM! #NUM! Peppas #VALUE! #VALUE! T-test #NUM! #NUM! Parameters for Hix.Crow. #VALUE! #VALUE! Korsmeyer-Peppas Equation-T-test #NUM! #NUM! #VALUE!t-Table at P0.05 (Two Tails), DF=n-2:- 0 #VALUE!

RESULTS Zero 1st order Matrix Peppas Hix.Crow.Sr.No. Time Avg. %R SD 0 0 0 0 0

1 -

Bharati Vidyapeeth Deemed University, Poona College of Pharmacy,

n =k =

MODEL FITTING: Residual Sum of Squares

PCP-Disso-v3Program developed by -Anant Ketkar, Vinay Patil and A.R. Paradkar,Dept. of Pharmaceutics,

Pune- 38, Maharashtra, India.

% Release (Average) & model fitting (with constraints)Name of the Drug = Batch = Date = Loading Dose in mg = 0 Total no. of Readings, including 'Zero-time' reading = Done by = Dissolution Medium = RPM = Volume of Dissolution Medium (ml) = Volume of Sample removed (ml) = Dilution Factor = 1Slope of Calibration curve = 29.5900Constant of Calibration curve = 0.9990R of Calibration curve = 0.1950Model Fitting (Average)-

R k Constraints for model fittingZero order #VALUE! #VALUE! Lower (%R) = 0T-test #NUM! #NUM! Upper (%R) = 01st order #VALUE! #VALUE!T-test #NUM! #NUM!

Matrix #VALUE! #VALUE! Best fit model- #VALUE!T-test #NUM! #NUM!

Peppas #VALUE! #VALUE!T-test #NUM! #NUM! Parameters for Hix.Crow. #VALUE! #VALUE! Korsmeyer-Peppas Equation-T-test #NUM! #NUM! #VALUE!t-Table at P0.05 (Two Tails), DF=n-2:- 0 #VALUE!

RESULTS Zero 1st order Matrix Peppas Hix.Crow.Sr.No. Time Avg. %R SD 0 0 0 0 0

1 -

Bharati Vidyapeeth Deemed University, Poona College of Pharmacy,

n =k =

MODEL FITTING: Residual Sum of Squares