pcp disso_

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pharmaceutical dissolution testing and analysis software ,\use for transdermal fulx calculation and for pharmacokinetic testing of dosage form\dont save the changes at the time of exit.

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CALIB-graph-SVDate :08.08.07Calibration curve for :Drug-IISolvent / Mobile Phase :1.2 pHWavelength (nm) :242Unit for Concentration :mcg/mlAnalytical Response :Abs.Done By :S MehtaEquation for the standard curve :Conc. =29.59Abs.+0.195R =0.9987
Welcome
ANANT KETKAR, VINAY PATIL & A. R. PARADKAR,Dept. of Pharmaceutics,Bharati Vidyapeeth Deemed University,POONA COLLEGE OF PHARMACY,Erandawane, Pune - 411 [email protected], [email protected], [email protected]
Developed by-
CALIB-graph-SDate :08.08.07Calibration curve for :Drug-IISolvent / Mobile Phase :1.2 pHWavelength (nm) :242Unit for Concentration :mcg/mlAnalytical Response :Abs.Done By :S MehtaEquation for the standard curve :Conc. =0.00Abs.+0.000R =0.0000
CALIB-graph-S
Concentration
Absorbance / AUC
Calibration Curve
CgDataPlease enter the following informationDate08.08.07Name of the drugDrug-IISolvent / Mobile phase used1.2 pHWavelength used in Nanometers242Unit usedmcg/mlAnalytical responseAbs.Done by (initials)S Mehta
Back to CALIB
NEXT
SAVE
Micrograms/mL
Nanograms/mL
Absorbance
AUC
NEXT
BACK
CALIBProgram for calibration curve**Instructions**Add the values only in 'YELLOW' coloured cells.Please do not change the cells with colours OTHER THAN YELLOW.var. of y =00t(intercept)000000No. of Points for Calibration000Curve =0000E Y^2(EY)^2slope^2InterceptE X^2(EX)^2nn-2X mean(X mean)^2E(X-Xmean)2CALIBRATION CURVE0000.0000000-2000Sr.No.Conc.AbsorbanceCorrelation CoefficientDFt-Table at P0.05 (Two Tails), DF=n-2IFY^2X^2X-Xmean1(R) =0.0000T-test0.0000.000112.706012t-Table at P0.05 (Two Tails), DF=n-2:-024.303023Slope =0.000033.182034Intercept =0.000042.77604552.57105662.44706772.36507882.30608992.2620910102.22801011112.20101112122.17901213132.1601314142.14501415152.13101516162.1201617172.1101718182.10101819192.09301920202.086020212.080222.0740232.0690242.0640252.060262.0560272.0520282.0480292.0450302.0420310320330340350360370380390402.0210410420430440450460470480490500
NEXT
GRAPH (Calibration Curve)
BACK
C-2Please enter the Slope, Constant& Correlation Coefficient (R) of'Concentration' Vs 'Absorbance/AUC' curveSlope29.59Constant0.999R0.195
NEXT
C-1
If you want to plot a Calibration/Standard Curve, click If you already have Slope, Constant & R of Calibration/Standard Curve, clickFor Single-Standard Comparison Method(without calibration curve), click
Here
Here
Here
Mode
Mode
DISSO
f 2 (Similarity factor)along with the ratios of Mean Dissolution Time and AUC
ABOUTPCP Disso v3
Calibration Curve
Mode
DISSO
f 2 (Similarity factor)along with the ratios of Mean Dissolution Time and AUC
ABOUTPCP Disso v3
Calibration Curve
Sheet1
DataFluxPlease enter the area of skin OR membrane used for the diffusion study-Area in cm2 =Skin/Membrane used =
Average FLUX
FLUX for all the sets
BACK
Graph
Results-FluxAll-SV
Results-Flux-SV
Flux-G-dataTimeFluxSpace00Avg. Flux (mcg/cm2/min)00Avg. Flux (mcg/cm2/h)00Avg. Time (min)00Avg. Time (h)00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
Results-FluxPCP-Disso-v3Program developed by -Anant Ketkar, Vinay Patil and A.R. Paradkar,Dept. of Pharmaceutics,Bharati Vidyapeeth Deemed University,Poona College of Pharmacy,Pune- 38, Maharashtra, India.% Release (Average with Flux))Name of the Drug =Batch =Date =Loading Dose in mg =0Total no. of Readings, including 'Zero-time' reading =Done by =Diffusion Medium =RPM =Volume of Dissolution Medium (ml) =Volume of Sample removed (ml) =Dilution Factor =1Slope of Calibration curve =29.5900Constant of Calibration curve =0.9990R of Calibration curve =0.1950minSkin/Membrane used =0Area for diffusion studies (cm2) =0Avg. Flux (mcg/cm^2/min)RESULTSAvg. Flux (mcg/cm^2/h)Sr.No.TimeAvg. %RSDAvg. TimeAvg. Flux (mcg/cm^2/min)Amt. (mcg)FluxAvg.TimeSpace=10.000.001BlankSpace000Avg. Dose0200030004000500060007000800090001000011000120001300014000150001600017000180001900020000210002200023000240002500026000270002800029000300003100032000330003400035000360003700038000390004000041000420004300044000450004600047000480004900050000
BACK
SAVE
BACK
SAVE
R-disso
GRAPH
RESULTS
With Model Fitting
Without Model Fitting
With Model Fitting
%Release (Average)With Q(t) & t(x%)
%Release (Average)Without Q(t) & t(x%)
%Release (All Sets)
%Release (Average)
%Release(Average with Q(t))
Without Model Fitting
Back to Dissolution Data Entry
Only Model Fitting(All Sets)
Back to MODE* WARNING *All previously entered data will be deleted.
%Release (with % Dissolution Efficiency, Mean Dissolution Time & Amount Released in mg)
FLUX
Fitting with Constraints
R-f2
GRAPH
RESULTS
With Q(t)
Without Q(t)
Back to MODE* WARNING *All previously entered data will be deleted.
Back tof2- Data Entry
Results-FluxAllPCP-Disso-v3Program developed by -Anant Ketkar, Vinay Patil and A.R. Paradkar,Dept. of Pharmaceutics,Bharati Vidyapeeth Deemed University,Poona College of Pharmacy,Pune- 38, Maharashtra, India.Flux for individual replicateName of the Drug =Batch =Date =Loading Dose in mg =0Total no. of Readings, including 'Zero-time' reading =Done by =Diffusion Medium =RPM =Volume of Dissolution Medium (ml) =Volume of Sample removed (ml) =Dilution Factor =1Slope of Calibration curve =29.5900Constant of Calibration curve =0.9990R of Calibration curve =0.1950Skin/Membrane used =0Area for diffusion studies (cm2) =0Avg. TimeFlux1Flux2Flux3Flux4Flux5Flux6(mcg/cm^2/min)Amt.mcg1Amt.mcg2Amt.mcg3Amt.mcg4Amt.mcg5Amt.mcg6Flux1Flux2Flux3Flux4Flux5Flux60.000.00Space=000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000450000000000004600000000000047000000000000480000000000004900000000000050000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
BACK
SAVE
BACK
SAVE
DISSOPCP Disso v3Add values only in SKY BLUE coloured cells.Extra Tools >>>CalculatorIt is a must to add the data in the fields marked with ##.Unit ConvertorDateName of the DrugBatch CodeDone by (Initials)Sample VolumeUnit used for calibration curve##=W21*$F$12Total No. of Readings, including 'Zero-time' reading##=W21*K20No. of Replicates1(between 1 to 6) ##Dissolution MediumDilution FactorDF-std. ModeRPMSlope='C-2'!D9=(($F$16*P20)+$F$17)*$Q$14=(P20*$I$16/I20)*$Q$14Volume of Dissolution Medium##Loading dose in mg ##Constant='C-2'!D10=(($F$16*P20)+$F$17)*AU20=(P20*$I$16/I20)*AU20Volume of Sample removed (if Fixed)##Dose 1Dose 4=(($F$16*P20)+$F$17)*$Q$14Dilution Factor (if Fixed)##Dose 2Dose 5Dilution Factor=(P20*$I$16/I20)*$Q$14Dose 3Dose 61Time inConc. of StandardSlope29.59Constant0.999PASTEStandardSampleDilutionDilution factorSr.No.TimeAbs1Abs2Abs3Abs4Abs5Abs6ABSAbsVolumeFactor(corrected for Zero)%R1%R2%R3%R4%R5%R6100000000-1SpaceUnit factorConc.Amt/Vol.removedAmt/Total Vol.QumulativeAmt.RemovedAmt. ReleasedConc. Remaining%ReleasedSpaceBlank%R2%R3%R4%R5%R6--000000Conc.Total vol. Of DM remainingAmt. Released%Released21000000000000010003Dose0.9990000000000010.99900014PASTE>>0.9990000000000010.999000250.99900000000000min/hrmin10.999000360.9990000000000010.999000470.99900000000000Space10.999000580.99900000000000Blank10.999000690.9990000000000010.9990007100.9990000000000010.9990008110.9990000000000010.9990009120.9990000000000010.99900010130.9990000000000010.99900011140.9990000000000010.99900012150.9990000000000010.99900013160.9990000000000010.99900014170.9990000000000010.99900015180.9990000000000010.99900016190.9990000000000010.99900017200.9990000000000010.99900018210.9990000000000010.99900019220.9990000000000010.99900020230.9990000000000010.99900021240.9990000000000010.99900022250.9990000000000010.99900023260.9990000000000010.99900024270.9990000000000010.99900025280.9990000000000010.99900026290.9990000000000010.99900027300.9990000000000010.99900028310.9990000000000010.99900029320.9990000000000010.99900030330.9990000000000010.99900031340.9990000000000010.99900032350.9990000000000010.99900033360.9990000000000010.99900034370.9990000000000010.99900035380.9990000000000010.99900036390.9990000000000010.99900037400.9990000000000010.99900038410.9990000000000010.99900039420.9990000000000010.99900040430.9990000000000010.99900041440.9990000000000010.99900042450.9990000000000010.99900043460.9990000000000010.99900044470.9990000000000010.99900045480.9990000000000010.99900046490.9990000000000010.99900047500.9990000000000010.999000480.999000000000000.99900049
'Calculate' with Volume Correction Factor
min
hr
Micrograms/mL
Nanograms/mL
'Calculate' without Volume Correction Factor
Calculator
Unit Convertor
Variable
Variable
Calculator
Unit Convertor
f2Determination of Similarity Factor (f2)Use Abs1, Abs2, and Abs3