despir e vestir os vasos - updatemedicina.com · embolia pulmonar . prevenção do tromboembolismo...
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Despir e vestir os vasos
António Pedro Machado
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Glicocálice
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Glicocálice endotelial
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Figure 1. Electron microscopy image of the endothelial glycocalyx in a coronary capillary
Curr Opin Lipidol 2005;16:507-511
Glycocalyx endotelial
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Curr Opin Lipidol 2005;16:507-511
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Curr Opin Lipidol 2005;16:507-511
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Disfunção do glicocálice
Doença
venosa Doença
aterosclerótica
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Curr Opin Lipidiol. 2005;16:507-511
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Q J Med 2008; 101:513–518
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Trends Cardiovasc Med. 2007;17:101-105
Glycocalyx – O escudo doce dos vasos
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A face visível (cosmética) da doença venosa
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A face grave da doença venosa
Varizes Úlcera de estase Flebotrombose Embolia pulmonar
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Sulodexida
Recuperação do
Glycocalyx
Recuperação da actividade
anticoagulante da parede
vascular
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Flebotrombose
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Embolia pulmonar
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Prevenção do tromboembolismo venoso com a
Rosuvastatina
N Engl J Med 2009;360:1851-61
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Figure 1. Systemic glycocalyx volume in hypercholesterolemic and normocholesterolemic subjects VG is signifi cantly reduced in FH patients compared to normocholesterolemic controls. Statin therapy partially restored glycocalyx volume. Mean ― SD (* p < 0.05 FH, rosuvastatin vs. FH, no treatment, # p < 0.05 FH, no treatment and FH, rosuvastatin vs. Control).
j lipid res. 2009 jan;50(1):148-53
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No tratamento das úlceras venosas
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3.5.2. Micronized Purified Flavonoid Fraction or Sulodexide for the Treatment of Venous Leg Ulcers
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Na claudicação intermitente
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Enfarte agudo do miocárdio
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JACC 1994.23;1:27-34
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Sulodexida – 97 mortes
Controlo – 140 mortes
0 100 200 300 400
7 –
6 –
5 –
4 –
3 –
2 –
1 –
0 –
Sulodexida
Controlo
Mo
rta
lid
ad
e g
lob
al (%
)
Dias
JACC 1994.23;1:27-34
Redução da mortalidade global com a
Sulodexida após EAM
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A doença despe o Médico veste
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