surgical treatment of atrial fibrilation: current concepts€¦ · rev bras cir cardiovasc vol.15...
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Renato A. K. KalilCirurgião Cardiovascular
Professor-Titular de Clínica Cirúrgica da UFCSPAProfessor Emérito do Programa de Pós-Graduação do IC/FUCMembro Titular da Academia Sul-Rio-Grandense de Medicina
Diretor Científico SBCCVPesquisador CNPq
Surgical Treatment of Atrial Fibrilation: Current Concepts
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Nome do Palestrante:
Renato A. K. Kalil
Título da Apresentação:
Surgical Treatment of Atrial Fibrilation: Current Concepts
Não possuo nenhum conflito de interesse relacionado a esta apresentação
I have no conflicts of interest, financial relationships or affiliations, related to this presentation, to disclose
Declaração de Potencial Conflito de Interesse
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Besides strong evidences of increased morbidity, stroke andmortality rates related to AF, a significant number of patients isleft untreated, even with readily available common anticoagulants.
Clinical trials comparing sinus rhythm reversion with rate controlpresent confounding results.Limited trials designs contribute to increased confusion.
In catheter ablation and surgery, the diversity of methods andoutcomes further confounds comparison of results.
Surgical Treatment of Atrial Fibrilation:Current ConceptsThe Problem (I)
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It has been well demonstrated that ablation and surgery, afterqualified indication, selection and treatment, results in more than 90% recovery of sinus rhythm, with low procedural risk.
Whether or not this corresponds to less clinical outcomes has notyet been proved by randomized clinical trials.In current ongoing investigation studies, there are no perspectives of consensus on sight.
Market issues contamination, in disregard to medical specialtiescollaboration/integration, further compromises a consensus.
Surgical Treatment of Atrial Fibrilation:Current ConceptsThe Problem (II)
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AF pathophysiology, burden and management are not familiar to many surgeons
Adding a new and controversed procedure to stablishedtechniques is a difficult task.
In this scenario, to describe the real space for AF surgery is a great challenge.
The exceptions are in the setting of mitral valve disease and in the practice of surgeons or centers devoted to AF treatment
Surgical Treatment of Atrial Fibrilation:Current ConceptsThe Problem (III)
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Hugh Calkins, Johns Hopkins Medical Institutions
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Ex.: Female (1), >65y (1), hypert (1), diabetes (1) = 4% strokerate/year = 40% stroke risk in 10 years
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AF Surgical Treatment
Risks
Mortality 1- 2%
Morbidity ~ 10%
Benefits:
Stroke
Late Mortality
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The Cox-Maze: A landmark procedure
• 1987 - Barnes Hospital, Washington UniversitySt. Louis, Mo
James L. Cox
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Early and late stroke after mitral valve replacement with a mechanical prosthesis: Risk factor analysis
of a 24-year experience
ConclusionsPersistent atrial fibrillation was the most significant risk factor for late stroke aftermechanical mitral valve replacement. Restoration of sinus rhythm with a maze procedurenearly eliminated the risk of late stroke, whereas neither closure of the left atrialappendage nor therapeutic anticoagulation prevented this complication.
Ko Bando, MD; Junjiro Kobayashi, MD; Mitsuhiro Hirata, MD, et al.J Thorac Cardiovasc Surg 2003;126:358-64
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Cox-Maze Procedure(Cirurgia ou Procedimento do Labirinto, para FA)
Annals of Thoracic Surgery 1993;55:578-80
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Haissaguerre M. NEJM 1998;339:659-66
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Left Atrial Procedure for Atrial Fibrillation.Sueda, T. et al. Ann Thorac Surg 1996;62:1796-800.
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Técnica cirúrgica simplificada pode ser eficaz no tratamento da fibrilação atrial crônica secundária a lesão valvar mitral?
Renato A. K. KALIL*, Gustavo G. LIMA*, Rogério ABRAHÃO*, Márcio L. STÜRMER*, Álvaro ALBRECHT*, Paulo MORENO*, Tiago L. L. LEIRIA*, Leonardo M. PIRES*, João Ricardo M. SANT'ANNA*, Paulo R. PRATES*, Ivo A. NESRALLA*
IVP n=7 Labirinto n=57
Rev Bras Cir Cardiovasc vol.15 n.2 São Paulo Apr./June 2000
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Ann Thorac Surg 2002;73:1169-1173.
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J Thorac Cardiovasc Surg. 2009 Aug;138(2):454-9.
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Mini-Maze Procedure
“The box lesion”
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Bulava et al. Ann Thorac Surg 2017; 104:2024-9
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Weimar T et al (Washington U/Barnes Hospital. Circ Arrhythm Electrophysiol. 2012;5:8-14
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A systematic review of minimally invasive surgical treatment for atrial fibrillation: a comparison of the Cox-Maze procedure, beating-heart epicardial ablation, and the hybrid procedure on safety and efficacy †
n= 1877 in 37 selected reports
Eur J Cardiothorac Surg. 2015;48(4):531-541. doi:10.1093/ejcts/ezu536
Eur J Cardiothorac Surg | © The Author 2015. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.
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The Society of Thoracic Surgeons Mitral Repair/Replacement Composite Score: A Report of
The Society of Thoracic Surgeons Quality Measurement Task Force
• MVrepair = 57.4% (35,114 of 61,201) • MVReplacement = 42.6% (26,087 of 61,201)• AF present = 32.2% (19,689 of 61,201)• Surgical ablation procedure performed in
61.5% of these patients (12,102 of 19,689).Badhwar V et al. Ann Thorac Surg 2012; 101:2265-2271
61,201 mitral valve procedures
Brazilian ByPass Registry: AF + Valve = 12/1722 = 0.7%
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Surgical Efficacy
• Depends on transmurality and lesions design• “Cut &Sew” warrants transmurality• RF, cryo, microwaves, diathermy, ultrasound,
etc are associated to variable success indices• Complete PV isolation in a “box lesion” like
design confers > 90% SR (similar to Cox-MazeIII/IV) in all AF modalities, being lone orassociated to structural disease, paroxysmalor long term.
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Surgical Risks
• Surgical mortality when associated ~= 2%• Surgical mortality for lone AF ~= 1%• Morbidity ~= 10% (reop for bleeding,
prolonged ventilation and LOS, infection, bradicardia, pacemaker, others)
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quarta-feira, 20 de dezembro de 2017
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2014 AHA/ACC/HRS Guideline for theManagement of Patients with Atrial Fibrillation
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Heart Rhythm June 2007(New document scheduled for 2017)
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Brazilian Society of CardiologyGuidelines for AF
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Obs.: No mention to “cutand sew” techniques in thisguideline
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STS 2017 Guidelines Surgical Ablation AFClass
I, A - at mitral valve surgery, to restore SRI, B - at Ao, CABG, Ao+CABG, to restore SR
IIa, B – for lone symptomatic AF refractory to drugs and catheterIIa, B – Cox-Maze III/IV lesion set is reasonable as compared to PVI alone
III – PVI alone is not recommended in LA>4.5cm or moderate MR
IIa, C – LAA exclusion in conjunction to ablation, for embolism preventionIIa, C – LAA exclusion in AF patients at time of cardiac surgery
I, C – Multidisciplinary assessment, planning and follow up are beneficial
Ann Thorac Surg 2017; 103: 329-41
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Surgical Treatment of Atrial Fibrilation: Current Concepts
Surgical ablation is effective for SR restoration in all AF forms SR restoration improves quality and may prolong life SR restoration reduces stroke rate Energy sources ablation, when properly used, are effective Left atrial and PVI with Cut & Sew is highly effective Surgical SR restoration is mandatory in mitral surgery Surgical SR restoration might improve outcomes after AVR and
CABG Moderate or high risk pts with Lone atrial fibrillation refractory to
drugs and catheter ablation, should consider surgery
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Renato A. K. KalilCirurgião Cardiovascular
Professor-Titular de Clínica Cirúrgica da UFCSPAProfessor Emérito do Programa de Pós-Graduação do IC/FUCMembro Titular da Academia Sul-Rio-Grandense de Medicina
Diretor Científico SBCCVPesquisador CNPq
Surgical Treatment of Atrial Fibrilation: Current Concepts