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Florianópolis-SCCentro de Cultura

e Eventos - UFSC03 a 06 de Outubro

VIII Congresso Brasileiro de

#respiraFunGo

ANAIS 2016

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Resumos VIII Congresso Brasileiro de Micologia

Abstracts VIII Brazilian Mycological Congress

Resúmenes VIII Congreso Brasileño de Micología

Florianópolis - SC, 03 a 06 de Outubro de 2016

Centro de Cultura e Eventos, Universidade Federal de Santa Catarina

1ª Edição

Copyright © 2016 - Sociedade Brasileira de Micologia

Todos os direitos reservados. Nenhuma parte desta obra pode serreproduzida, arquivada ou transmitida, em qualquer forma ou por qualquer meio, sem

permissão da Sociedade Brasileira de Micologia.

Todos os resumos neste livro foram reproduzidos de cópias fornecidas pelos autores e o conteúdo dos textos é de exclusiva responsabilidade dos seus

autores. A Coordenação VIII Congresso Brasileiro de Micologia e o comitê de avaliação não se responsabilizam por consequências decorrentes do uso de quaisquer dados, afirmações e/ou opiniões inexatas ou que conduzam a erro

publicadas neste livro de resumos.

Coordenação do VIII Congresso Brasileiro de Micologia

Editoração:Maria Alice Neves & Admir José Giachini

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Micologia Médica - Antifúngicos

ANTIFUNGAL ACTIVITY OF 7-HYDROXYCALAMENENE-RICH ESSENTIAL OIL

NANOEMULSION

Mariana Maria Barros de Azevedo1; Catia Amancio Almeida

1; Maria Bárbara Faria Cardoso da Silva

1;

Francisco Celio Maia Chaves2; Eduardo Ricci Júnior

1; Humberto Ribeiro Bizzo

3; Daniela Sales Alviano

1;

Celuta Sales Alviano1.

E-mail: marimbarros@gmail.com

(1)Federal University of Rio de Janeiro - Rio de Janeiro, Brazil;

(2)EMBRAPA Western Amazon - Amazon,

Brazil; (3)

EMBRAPA Food Technology - Rio de Janeiro, Brazil

RESUMO Nanoemulsions, unlinke microemulsions, are metastable submicron oil-in-water dispersions with droplet

diameter in the range of 10-100 nm. Potential advantages of nanoemulsions over conventional emulsions like

high physical stability, can be sterilised by filtration, high bioavailability and low turbidity make them attractive

systems for application in food, cosmetics and pharmaceutical industry. Nanoemulsions serve as delivery

agents for lipophilic bioactive compounds such as drug in the pharmaceutical industry and, for flavors and

antimicrobial agents in the food industry, for solubilizing water-insoluble pesticides in agrochemical industry

and as vehicle for skincare and personal products in cosmetics. The leaves from Croton cajucara Benth. (family

Euphorbiaceae), a shrub from the Amazon, have been locally used in folk medicine to treat diabetes, malaria,

gastrointestinal and liver disorders. A chemotype of this species was found with an essential oil rich in 7-

hydroxycalamenene. 7-hydroxycalamenene is a hydroxylated sesquiterpene of molecular weight 218 g/mol

found in Heritiera ornithocephala, Eremophila drummondii, Heteroscyphus planus, Tilia europea, Morus

alba, Ulmus thomasii and other elm species, and methanolic and dichloromethanic extracts of Bazzania

trilobata. This substance is reported to have antifungal activity against Botrytis cinerea, Cladosporium

cucumerinum, Phythophthora infestans, Pyricularia oryzae and Septoria tritici. The aim of this study was to

evaluate the inhibitory activity of 7-hydroxycalamenene-rich essential oil nanoemulsion against filamentous

fungi and yeasts. Minimum inhibitory concentration (MIC) was evaluated in triplicate according standard

methods from Clinical and Laboratory Standards Institute (CLSI) M27-A2 and M38-A2. All species tested

were sensitive to nanoemulsion at concentrations ranging from 12.21 μg/mL for Absidia cylindospora, Mucor

ramosissimus and Syncephalastrum racemosum, to 6578.95 μg/mL for Candida

dubliniensis, C. famata, C. tropicalis and C. glabrata. These results suggest a possible antifungal potential of 7-

hydroxycalamenene-rich essential oil nanoemulsion formulation against tested fungi, although further tests are

necessary.

APOIO Financial support: FAPERJ, CNPq and CAPES.