2nd Advanced School in Genetic Manipulation of Parasitic ProtozoaRECENT ADVANCES IN CRISPR-CAS9 GENOME EDITING

Rio de Janeiro 16-20th July 2018Instituto de Biofísica Carlos Chagas FilhoFederal University of Rio de Janeiro (UFRJ)

Organisers:Ana Paula Lima (UFRJ), Jeremy Mottram (University of York),Santuza Teixeira (UFMG), Eva Gluenz (University of Oxford)

Lecturers:David Horn, University of Dundee Richard McCulloch, University of Glasgow Carlos Robello, Institut Pasteur de Montevideo Esteban Serra, IBR CONICET, RosarioLia Soares Medeiros, Fiocruz, CuritibaLilach Sheiner, University of Glasgow Carolina Catta-Preta, University of YorkTom Beneke, University of OxfordGabriela Burle-Caldas, UFMG

This course will provide students from neglected disease endemic countries and the UK withtheoretical and practical training in the latest technologies for exploitation of genomes of parasiticprotozoa using genetic manipulation. The parasites covered in the theoretical component of thecourse will include Leishmania spp., Trypanosoma cruzi, T. brucei and Toxoplasma gondii and willdescribe how genetics can be used to validate drug targets and to identify novel molecularmechanisms involved in host-parasite interactions. In the practical element of the course,students will use CRISPR-cas9 to carry out genome editing of L. mexicana or Trypanosoma cruzi togenerate gene deletion mutants and mutants with in situ gene epitope tags.

Application forms and further information on travel bursaries for early career researchers will be available from 1 April 2018 atntd-network.orgOr contact: ntd.network@durham.ac.uk

Funding: GCRF Global Network for NTDs