Publicação eletrônica bimestral do Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa - INCT - Regenera

Ano I - Edição 04 / Setembro de 2017

Notícias do cenário mundial sobre Medicina Regenerativa - Julho e Agosto

DJ Genético: As células em desenvolvimento recombinam seus genes

Fonte: Babraham Institute Moving genes about could help cells to respond to change according to scientists. Changing the location of a gene within a cell alters its activity. Contrary to expectations, this latest study reveals that each gene doesn’t have an ideal location in the cell but are constantly moving. https://www.sciencedaily.com/releases/2017/07/170705133028.htm

Nova tecnologia para manipular célula pode ajudar a tratar Parkinson, artrite, outras doenças

Fonte: Northwestern University A groundbreaking advancement in materials could potentially help patients requiring stem cell therapies for spinal cord injuries, stroke, Parkinson’s disease, Alzheimer’s disease, arthritic joints or any other condition requiring tissue regeneration, according to a new study. https://www.sciencedaily.com/releases/2017/07/170710160943.htm

Terapia com células-tronco para tratar metastasse do câncer de pele no cérebroFonte: Brigham and Women’s Hospital https://www.sciencedaily.com/releases/2017/07/170710161006.htm

Terapia celular para cancer é aprovada por conselheiros do FDA

Fonte: Heidi LedfordTreatment shows promise in young people with leukaemia, but safety risks abound.http://www.nature.com/news/engineered-cell-therapy-for-cancer-gets-thumbs-up--from-fda-advisers-1.22304

Células-tronco podem ajudar na melhora da cicatrização da lesão da córnea Fonte: Wiley https://www.sciencedaily.com/releases/2017/07/170731114649.htm

Em direção a uma terapia celular segura e com escala para tratar a diabetes tipo 1 simplificando a diferenciação das células beta.Fonte: University of Copenhagen The Faculty of Health and Medical SciencesWith the vision of providing a cell therapy for type 1 diabetes patients, scientists have identified a unique cell surface protein present on human pancreatic precursor cells providing for the first time a molecular handle ...https://www.sciencedaily.com/releases/2017/07/170731114658.htm

Células-tronco humanas se mantem no tecido para o reparo de lesão na medula espinhal de ratosFonte: University of California - San Diego More than one-and-a-half years after implantation, researchers report that human neural stem cells (NSCs) grafted into spinal cord injuries in laboratory rats displayed continued growth and maturity, with functional recovery beginning one year after grafting.https://www.sciencedaily.com/releases/2017/08/170828143003.htm

Sistema de liberação de células-tronco “Nano-in-micro” pode recuperar o fluxo sanguíneo após lesão Fonte: American Chemical SocietyWhen blood flow is reduced or cut to tissues, cells are deprived of oxygen and nutrients, which can lead to cell death if blood flow isn’t efficiently restored. https://www.sciencedaily.com/releases/2017/07/170719084830.htm

Cientistas descobrem que a Vitamina C regula a função das Células-tronco e freia o desenvolvimento da leucemiaFonte: UT Southwestern Medical Centerhttps://www.sciencedaily.com/releases/2017/08/170821134244.htm

O avanço no campo das células-tronco para uso na descoberta de drogas e terapia celular Fonte :University of Wisconsin-Madison Using an automated screening test, researchers have invented an all-chemical replacement for the confusing, even dangerous materials, now used to grow stem cells. https://www.sciencedaily.com/releases/2017/07/170714164909.htm

CRISPR pode elucidar a síndrome da insuficiência da medula óssea pediátrica

Fonte: Washington University in St. LouisUsing the gene editing technology CRISPR, scientists have shed light on a rare, sometimes fatal syndrome that causes children to gradually lose the ability to manufacture vital blood cells. The research suggests new lines of investigation into how to treat this condition — dyskeratosis congenita — which is characterized by shortened telomeres. Short telomeres lead to progressive DNA damage that accumulates over time. https://www.sciencedaily.com/releases/2017/07/170727122658.htm

Mini-cérebros produzidos em laboratório demonstram como o crescimento do órgão mantém o balanço neuronal

Fonte: Yale University Scientists can now explore in a laboratory dish how the human brain develops by creating organoids -- distinct, three-dimensional regions of the brain. Scientists coaxed early stage stem cells to create and fuse two types of organoids from different brain regions to show how the developing brain maintains proper balance of excitatory and inhibitory neurons.https://www.sciencedaily.com/releases/2017/07/170727141613.htm

Terapia com células-tronco pode atacar seletivamente alvos específicos nos tecidos cancerososFonte: University of California, Irvine https://www.sciencedaily.com/releases/2017/07/170726163736.htm

A dinâmica da difusão tem um papel essencial na regularização das células tronco e do desenvolvimento tecidual Fonte: Institute of Neural Regeneration & Tissue Engineeringhttps://www.sciencedaily.com/releases/2017/07/170726102932.htm

Cientistas regeneram as células da retina de camundongosFonte: University of Washington Health Sciences/UW Medicine Scientists have succeeded in regenerating functional retinal cells in adult mice. https://www.sciencedaily.com/releases/2017/07/170726132054.htm

Agentes Quimioterápicos anti-câncer inibem o crescimento do Glioblastoma e resistência a radiação. Fonte: University of Alabama at Birmingham A unique and previously unidentified molecular mechanism has been discovered that maintains glioma stem cells, report investigators. They have tested it as a potential therapeutic target in glioblastoma, using a novel small molecule inhibitor they designed and synthesized https://www.sciencedaily.com/releases/2017/07/170724161247.htm

A Droga anti-inflamatória Celecoxib pode promover sobrevivência das células-tronco e cicatrização de feridas em camundongos Fonte: ElsevierScientists have found a new way to protect stem cells from harsh inflammation during wound repair. https://www.sciencedaily.com/releases/2017/07/170720095225.htm

Fonte: University of Zurich For the first time, researchers have shown that hematopoietic stem cells detect infectious agents themselves and begin to divide – that is, without signals from growth factors. https://www.sciencedaily.com/releases/2017/07/170720131831.htm

Reação INATA das células-tronco hematopoéticas a infecções graves

Utilização de microRNA pode trocar os subtipos de gliobastomaFonte: Brigham and Women’s Hospitalhttps://www.sciencedaily.com/releases/2017/07/170713153027.htm

As células-tronco são a conexão entre bactéria e câncer?Fonte: Max-Planck-Gesellschafthttps://www.sciencedaily.com/releases/2017/08/170817092807.htm

Utilização de códigos de barras para rastrear o desenvolvimento de célulasForce: German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)https://www.sciencedaily.com/releases/2017/08/170816134645.htm

Células-tronco com receptor de estrogênio encontradas nas glândulas mamáriasFonte: Université libre de Bruxelleshttps://www.sciencedaily.com/releases/2017/08/170816100321.htm

Células - tronco neurais movidas por campos elétricos no cérebro de camundongos

Fonte: University of California – DavisElectric fields can be used to guide neural stem cells transplan-ted into the brain towards a specific location. This discovery opens possibilities for effectively guiding stem cells to repair brain damage. https://www.sciencedaily.com/releases/2017/07/170711141353.htm

Utilização de Células-tronco doadas para tratamento de lesão de medula espinhal

Proteína da Medula Óssea pode ser a chave para melhorar os transplantes com Células-troncoFonte: University of Pennsylvaniahttps://www.sciencedaily.com/releases/2017/08/170828183445.htm

Sistema Imune humano em modelo de camundongos é inadequado para os estudos das Células-troncoFonte: Stanford University Medical Centerhttps://www.sciencedaily.com/releases/2017/08/170822123842.htm

De Onde vem as Células cardíacas? Source: Sanford-Burnham Prebys Medical Discovery Institutehttps://www.sciencedaily.com/releases/2017/08/170822104843.htm

A Vitamina C pode estimular a morte das células-tronco sanguíneas cancerígenasFonte: NYU Langone Health / NYU School of Medicinehttps://www.sciencedaily.com/releases/2017/08/170817141722.htm

As células-tronco são a conexão entre bactéria e câncer?Fonte: Max-Planck-Gesellschafthttps://www.sciencedaily.com/releases/2017/08/170817092807.htm

Como a glutamina pode controlar programas gênicos nas célulasFonte:University of Alabama at Birminghamhttps://www.sciencedaily.com/releases/2017/08/170815120545.htm

Nova maneira de ativar células-tronco para fazer o cabelo crescerSource: University of California - Los Angeles Health Scienceshttps://www.sciencedaily.com/releases/2017/08/170814134816.htm

Novas informações sobre como as células imunológicas são formadasFonte: Karolinska Institutethttps://www.sciencedaily.com/releases/2017/08/170810104841.htm

O envelhecimento é exacerbado por alterações do ritmo circadiano das células-troncoFonte: Institute for Research in Biomedicine (IRB Barcelona)https://www.sciencedaily.com/releases/2017/08/170810120431.htm

Transformando células da pele em células produtoras de insulinaFonte: University of Bergenhttps://www.sciencedaily.com/releases/2017/08/170809073709.htm

Descoberta de novos genes que regulam as metástases cerebrais em pacientes com câncer de pulmãoFonte: McMaster Universityhttps://www.sciencedaily.com/releases/2017/08/170808183336.htm

The first few weeks after sperm meets egg still hold many mysteries. Among them: what causes the process to fail, leading to many cases of infertility. But scientists haven’t had a good way to explore the biology behind this phenomenon. Now, a new achievement using human stem cells could give researchers a chance to see what they couldn’t before, while avoiding ethical issues associated with studying actual embryos.https://www.sciencedaily.com/releases/2017/08/170808074259.htm

A descoberta de células-tronco na renovação do coraçãoFonte: University of Southern California - Health Scienceshttps://www.sciencedaily.com/releases/2017/08/170807151708.htm

Membranas do tecido fetal podem ajudar a transformar a Medicina RegenerativaFonte: Wileyhttps://www.sciencedaily.com/releases/2017/08/170830103648.htm

Saco amniótico em placa de cultura: as células-tronco formam estruturas que podem ajudar as pesquisas na área da infertilidade

Fonte: Michigan Medicine - University of Michigan

Fonte: Society for NeuroscienceA new study in mice details a potential therapeutic strategy that uses stem cells to promote recovery of motor activity after spinal cord injury.https://www.sciencedaily.com/releases/2017/08/170828131733.htm

Boletim INCT é um publicação on line bimestral. As notícias publicadas são adquiridas na internet pelas principais fontes na área da Ciência. As referências estão citadas em cada texto, assim como os seus devidos links. Caso tenha interesse em divulgar ou solicitar informações da área de pesquisa associada a Medicina Regenerativa, favor fazer contato por e-mail o qual será submetido a coordenação do INCT-Regenera. inct.regenera@gmail.com ::: http://www.inctregenera.org.br ::: FaceBook: fb.me/inctregenera

Terapia gênica utilizando a pele poderia tratar muitas doenças, inclusive a obesidade

Novos hidrogeis responsivos a estímulos abrem a porta para aplicações futuras dos materiais biológicos e biomédicosFonte: The Hong Kong University of Science and Technologyhttps://www.sciencedaily.com/releases/2017/08/170803155845.htm

Terapia com células-tronco para fibrose pulmonarFonte: University of North Carolina Health Carehttps://www.sciencedaily.com/releases/2017/08/170803091928.htm

ONC201 pode inibir a autorenovação das células-tronco cancerígenas modificando a sua expressão gênicaFonte: PLOShttps://www.sciencedaily.com/releases/2017/08/170802152541.htm

Fonte: MedicaXpressWhen the immune system is imbalanced, either due to overly-active cells or cells that suppress its function, it causes a wide range of diseases, from psoriasis to cancer. By manipulating the function of certain immune cells, called T cells, researchers could help restore the system’s balance and create new treatments to target these diseases.https://medicalxpress.com/news/2017-08-reveals-reprogram-cells-immune.html

Fonte: MedicaXpresshttps://medicalxpress.com/news/2017-08-gene-therapy-skin-diseases-obesity.html

Estudos Demonstram como reprogramar células do sistema imune

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